AKT1S1 and EIF6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AKT1S1	EIF6
Gene Name		AKT1 substrate 1 (proline-rich)	eukaryotic translation initiation factor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Cellular Response To Heat	Ribosomal Subunit Export From Nucleus Translational Initiation Mature Ribosome Assembly Ribosomal Large Subunit Biogenesis
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) HSF1-dependent transactivation PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		12 interactors: AKT1 AKT2 EIF6 MAPKAP1 MLST8 MTOR RICTOR RPS6KA5 RPTOR TCEA2 YWHAG YWHAQ	38 interactors: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP C4orf27 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FHL2 FUNDC2 GIT1 GNB2L1 HIP1 ITGB4 KIAA1377 LRIF1 MRPS31 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 RPL6 SEPT3 TK1 UPF3B USP33 WFS1 XRN2 ZBTB26
Entrez ID		84335	3692
HPRD ID		12441	04221
Ensembl ID		ENSG00000204673	ENSG00000242372
Uniprot IDs		Q96B36	P56537
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorylation Response To Peptide Hormone Positive Regulation Of T Cell Activation Cellular Response To Organonitrogen Compound Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Phosphorylation Response To Peptide Regulation Of Fatty Acid Beta-oxidation Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell-cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Rac GTPase Activity TOR Signaling Fc Receptor Signaling Pathway Positive Regulation Of TOR Signaling Cellular Response To Hormone Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Heat	Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Proteolysis Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Translation Positive Regulation Of Peptidase Activity Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Cell Projection Morphogenesis Cell Projection Organization Response To Stress Cell Part Morphogenesis Gene Expression Axon Guidance Regulation Of Signaling Positive Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of Binding Negative Regulation Of Defense Response To Virus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Hydrolase Activity Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Cell Morphogenesis Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Modification-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transferase Activity Axonogenesis Response To External Stimulus Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Innate Immune Response
Tagcloud ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	40s 60s 80s associates biogenesis cerevisiae cessation depleted designated encodes imbalance lysates maps mer monosomes mr polyribosomes polysomal prevents ribosomal ribosomes saccharomyces stoichiometric subunits tif6 true ultimately xvi yeast
Tagcloud (Difference) ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	40s 60s 80s associates biogenesis cerevisiae cessation depleted designated encodes imbalance lysates maps mer monosomes mr polyribosomes polysomal prevents ribosomal ribosomes saccharomyces stoichiometric subunits tif6 true ultimately xvi yeast
Tagcloud (Intersection) ?