AKT1S1 and RPS6KA5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		AKT1S1	RPS6KA5
Description		AKT1 substrate 1	ribosomal protein S6 kinase A5
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Protein Serine/threonine Kinase Inhibitor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cytoplasmic Translation Negative Regulation Of Protein Kinase Activity Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Size Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of TORC1 Signaling	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization
Pathways		MTOR signalling mTORC1-mediated signalling AKT phosphorylates targets in the cytosol HSF1-dependent transactivation Constitutive Signaling by AKT1 E17K in Cancer	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS			A body shape index ( 34021172) Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: AKT1 AKT2 EIF6 FZR1 MTOR RPS6KA5 TCEA2 YWHAG YWHAQ	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		84335	9252
HPRD ID		12441	06789
Ensembl ID		ENSG00000204673	ENSG00000100784
Uniprot IDs		Q96B36	O75582
PDB IDs		5WBL 5WBU 5WBY 6SB0	1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Translational Initiation Response To Insulin Positive Regulation Of Translation TORC1 Signaling TOR Signaling Cellular Response To Insulin Stimulus Regulation Of Translational Initiation Response To Peptide Hormone Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Translation Positive Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Translation Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translational Initiation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Energy Reserve Metabolic Process Negative Regulation Of Fatty Acid Transport Response To Hormone Post-transcriptional Regulation Of Gene Expression Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Regulation Of Primary Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of TORC1 Signaling Anoikis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Small Molecule Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC2 Signaling Translation Protein Serine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction
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