AKT1S1

Description		AKT1 substrate 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Cytoplasmic Translation Negative Regulation Of Protein Kinase Activity Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Size Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of TORC1 Signaling
Pathways		MTOR signalling mTORC1-mediated signalling AKT phosphorylates targets in the cytosol HSF1-dependent transactivation Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: AKT1 AKT2 EIF6 FZR1 MTOR RPS6KA5 TCEA2 YWHAG YWHAQ
Entrez ID		84335
HPRD ID		12441
Ensembl ID		ENSG00000204673
Uniprot IDs		Q96B36
PDB IDs		5WBL 5WBU 5WBY 6SB0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Translational Initiation Response To Insulin Positive Regulation Of Translation TORC1 Signaling TOR Signaling Cellular Response To Insulin Stimulus Regulation Of Translational Initiation Response To Peptide Hormone Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Translation Positive Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Translation Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translational Initiation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Energy Reserve Metabolic Process Negative Regulation Of Fatty Acid Transport Response To Hormone Post-transcriptional Regulation Of Gene Expression Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Regulation Of Primary Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of TORC1 Signaling Anoikis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Small Molecule Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC2 Signaling Translation Protein Serine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport
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