TBXA2R and RAB11A

Number of citations of the paper that reports this interaction (PMID 16126723)
19

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, imaging technique)
HPRD (in vivo, in vitro)

		TBXA2R	RAB11A
Gene Name		thromboxane A2 receptor	RAB11A, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane	Spindle Pole Mitochondrion Multivesicular Body Trans-Golgi Network Kinetochore Microtubule Cytosol Plasma Membrane Transport Vesicle Axon Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Protein Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Syntaxin Binding Myosin V Binding
	Biological Process	Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Blood Coagulation Second-messenger-mediated Signaling Platelet Activation Response To Lipopolysaccharide Thromboxane A2 Signaling Pathway Response To Drug Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction	Cytokinesis Renal Water Homeostasis Water Transport Intracellular Protein Transport Exocytosis Organelle Organization Mitotic Metaphase Plate Congression Positive Regulation Of Epithelial Cell Migration Regulation Of Multivesicular Body Size Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Assembly Positive Regulation Of Axon Extension Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Transmembrane Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Exosomal Secretion
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signal amplification GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (12/13) signalling events Platelet activation, signaling and aggregation Eicosanoid ligand-binding receptors	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Vasopressin regulates renal water homeostasis via Aquaporins Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Aquaporin-mediated transport Anchoring of the basal body to the plasma membrane
Drugs		Ridogrel
Diseases
GWAS
Protein-Protein Interactions		24 interactors: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNB2L1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKACA PRKCA PRKG1 PSMA7 PSME3 PTGIR RAB11A RAF1 RPGRIP1L YWHAZ	28 interactors: CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB3IL1 RABGGTB RCHY1 SEC13 STX4 TBXA2R TDP2 WDR44 YWHAG
Entrez ID		6915	8766
HPRD ID		01768	05715
Ensembl ID		ENSG00000006638	ENSG00000103769
Uniprot IDs		P21731 Q05C92 Q0VAB0	P62491
PDB IDs		1LBN	1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Wound Healing G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Wounding Cell Activation Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signal Transduction Positive Regulation Of CAMP Metabolic Process Signaling Cell Communication Regulation Of Signaling Dopamine Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Stimulus Negative Regulation Of Signal Transduction Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Intracellular Signal Transduction Regulation Of Cyclase Activity Response To Stress Cellular Response To Catecholamine Stimulus Activation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Response To Stimulus Cellular Response To Fatty Acid Positive Regulation Of Lyase Activity Positive Regulation Of Signal Transduction Apoptotic Process Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Glucagon Cellular Response To Prostaglandin E Stimulus Programmed Cell Death Cell Death Negative Regulation Of Transferase Activity	Protein Transport Establishment Of Protein Localization Protein Localization Establishment Of Localization In Cell Cellular Localization Organelle Localization Vesicle-mediated Transport Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Transport Exocytosis Regulation Of Signal Transduction Post-Golgi Vesicle-mediated Transport Membrane Organization Intracellular Transport Regulation Of Signaling Golgi Vesicle Transport Cell Death Death Insulin Secretion Secretion By Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Synaptic Transmission Negative Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulated Secretory Pathway Regulation Of Synaptic Plasticity Regulation Of Body Fluid Levels Amyloid Precursor Protein Catabolic Process Cell-cell Signaling Peptide Hormone Secretion Secretion Peptide Secretion Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Apoptotic Process Cell Cycle Cell Communication Negative Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Cycle Process Negative Regulation Of Kinase Activity Hormone Secretion Regulation Of Protein Kinase Activity Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process
Tagcloud ?		alleles asthma beas bronchodilator bsmcs disequilibrium eosinophil expiratory fef fev1 forced fvc h2 haplotype haplotypes homozygotes redefined remodelling rs1131882 rs2238631 rs2238632 rs2238633 rs2238634 snp1 snp2 snp3 snp4 thromboxane zygotes	c2 compartments displays fip fip1 fip2 fip3 fip5 fips gtpases hela illumination integral lactc2 live membranes microscopy overlap overlapped overlapping pericentriolar phosphatidylserine probe ps recycling structured tubular
Tagcloud (Difference) ?		alleles asthma beas bronchodilator bsmcs disequilibrium eosinophil expiratory fef fev1 forced fvc h2 haplotype haplotypes homozygotes redefined remodelling rs1131882 rs2238631 rs2238632 rs2238633 rs2238634 snp1 snp2 snp3 snp4 thromboxane zygotes	c2 compartments displays fip fip1 fip2 fip3 fip5 fips gtpases hela illumination integral lactc2 live membranes microscopy overlap overlapped overlapping pericentriolar phosphatidylserine probe ps recycling structured tubular
Tagcloud (Intersection) ?