TBXA2R and PSME3

Number of citations of the paper that reports this interaction (PubMedID 17499743)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid, two hybrid)

		TBXA2R	PSME3
Description		thromboxane A2 receptor	proteasome activator subunit 3
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GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Proteasome Activator Complex Membrane Ciliary Basal Body
	Molecular Function	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor	Proteasome assembly
Drugs		Ridogrel Seratrodast Morniflumate
Diseases
GWAS
Interacting Genes		35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15	63 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CEBPA CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FMR1 FOXD4L1 FXR1 FXR2 GPATCH2L HSPA5 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PICK1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10
Entrez ID		6915	10197
HPRD ID		01768	05500
Ensembl ID		ENSG00000006638	ENSG00000131467
Uniprot IDs		P21731 Q05C92 Q0VAB0	B3KQ25 P61289 V9HWJ8
PDB IDs		8XJN 8XJO	7YQC 7YQD
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Staurosporine Response To Nutrient Levels Protein Binding Protein Domain Specific Binding Nucleus Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Response To Nutrient Levels Macromolecule Catabolic Process Cytosol Positive Regulation Of Protein Metabolic Process Cellular Response To Alkaloid Post-translational Protein Modification Response To Xenobiotic Stimulus Neuron Projection Response To Alkaloid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Leukocyte Apoptotic Process Response To UV Proteolysis Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Mononuclear Cell Differentiation Protein-containing Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Translation Regulator Activity Cellular Response To Glucose Starvation Cellular Response To Actinomycin D Positive Regulation Of Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Developmental Process Modification-dependent Protein Catabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of RNA Metabolic Process Protein Destabilization Response To Actinomycin D HLH Domain Binding Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Stability Leukocyte Differentiation Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing Disordered Domain Specific Binding Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process
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