TBXA2R and RPGRIP1L

Number of citations of the paper that reports this interaction (PMID 19464661)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)

		TBXA2R	RPGRIP1L
Gene Name		thromboxane A2 receptor	RPGRIP1-like
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Centrosome Cytosol Cell-cell Junction Tight Junction Cilium Axoneme Ciliary Transition Zone Ciliary Basal Body
	Molecular Function	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Thromboxane A2 Receptor Binding
	Biological Process	Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Blood Coagulation Second-messenger-mediated Signaling Platelet Activation Response To Lipopolysaccharide Thromboxane A2 Signaling Pathway Response To Drug Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction	In Utero Embryonic Development Establishment Of Planar Polarity Kidney Development Liver Development Organelle Organization Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cerebellum Development Lateral Ventricle Development Olfactory Bulb Development Corpus Callosum Development Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Cilium Assembly Camera-type Eye Development Nose Development Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Pericardium Development Cochlea Development
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signal amplification GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (12/13) signalling events Platelet activation, signaling and aggregation Eicosanoid ligand-binding receptors	Organelle biogenesis and maintenance Hedgehog 'off' state Signaling by Hedgehog Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs		Ridogrel
Diseases
GWAS			Bipolar disorder ( 21254220)
Protein-Protein Interactions		24 interactors: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNB2L1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKACA PRKCA PRKG1 PSMA7 PSME3 PTGIR RAB11A RAF1 RPGRIP1L YWHAZ	1 interactors: TBXA2R
Entrez ID		6915	23322
HPRD ID		01768	17204
Ensembl ID		ENSG00000006638	ENSG00000103494
Uniprot IDs		P21731 Q05C92 Q0VAB0	H3BV03 Q68CZ1
PDB IDs		1LBN	2YRB
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Wound Healing G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Wounding Cell Activation Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signal Transduction Positive Regulation Of CAMP Metabolic Process Signaling Cell Communication Regulation Of Signaling Dopamine Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Stimulus Negative Regulation Of Signal Transduction Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Intracellular Signal Transduction Regulation Of Cyclase Activity Response To Stress Cellular Response To Catecholamine Stimulus Activation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Response To Stimulus Cellular Response To Fatty Acid Positive Regulation Of Lyase Activity Positive Regulation Of Signal Transduction Apoptotic Process Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Glucagon Cellular Response To Prostaglandin E Stimulus Programmed Cell Death Cell Death Negative Regulation Of Transferase Activity	Thromboxane A2 Signaling Pathway Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Vasoconstriction Positive Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Positive Regulation Of Angiogenesis Second-messenger-mediated Signaling Regulation Of Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Platelet Activation Response To Nutrient Regulation Of Angiogenesis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Cellular Metal Ion Homeostasis Blood Coagulation Inflammatory Response Hemostasis Response To Nutrient Levels Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Extracellular Stimulus Metal Ion Homeostasis Response To Bacterium Response To Drug Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Cellular Homeostasis Response To Wounding Response To Other Organism Positive Regulation Of GTPase Activity
Tagcloud ?		alleles asthma beas bronchodilator bsmcs disequilibrium eosinophil expiratory fef fev1 forced fvc h2 haplotype haplotypes homozygotes redefined remodelling rs1131882 rs2238631 rs2238632 rs2238633 rs2238634 snp1 snp2 snp3 snp4 thromboxane zygotes	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp nphp1 nphp4 tgl throw ttl
Tagcloud (Difference) ?		alleles asthma beas bronchodilator bsmcs disequilibrium eosinophil expiratory fef fev1 forced fvc h2 haplotype haplotypes homozygotes redefined remodelling rs1131882 rs2238631 rs2238632 rs2238633 rs2238634 snp1 snp2 snp3 snp4 thromboxane zygotes	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp nphp1 nphp4 tgl throw ttl
Tagcloud (Intersection) ?