TBXA2R and SLC41A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBXA2R	SLC41A1
Description		thromboxane A2 receptor	solute carrier family 41 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck	Plasma Membrane Membrane Basolateral Plasma Membrane Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity Magnesium:sodium Antiporter Activity
	Biological Process	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Monoatomic Ion Transport Monoatomic Cation Transport Intracellular Magnesium Ion Homeostasis Magnesium Ion Transport Metal Ion Transport Sodium Ion Transmembrane Transport Cellular Response To Magnesium Ion Magnesium Ion Transmembrane Transport
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor	Metal ion SLC transporters
Drugs		Ridogrel Seratrodast Morniflumate
Diseases
GWAS			Allergic sensitization ( 30013184) Atrial fibrillation ( 30061737) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Monocyte count ( 27863252 32888494) Parkinson's disease ( 28892059 21738487 19915576) Plateletcrit ( 32888494) Prostate cancer ( 25217961) Prostate-specific antigen levels ( 25434496 23269536) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15	32 interacting genes: AMIGO1 AQP6 AVPR2 CD79A CLN5 ELOVL7 ERGIC3 FAM209A FFAR2 FFAR3 GJA5 GJB5 GPR101 GPR152 GPR42 KASH5 LHFPL5 OPRM1 SLC10A1 SLC10A6 SLC13A4 SLC23A2 SSMEM1 SYNDIG1 SYPL2 TAAR9 TBXA2R TLCD4 TMEM237 TMEM248 TMEM31 TRHR
Entrez ID		6915	254428
HPRD ID		01768	15388
Ensembl ID		ENSG00000006638	ENSG00000133065
Uniprot IDs		P21731 Q05C92 Q0VAB0	B2RMP2 Q8IVJ1
PDB IDs		8XJN 8XJO
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH	Membrane G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Positive Regulation Of Vasoconstriction Bile Acid:sodium Symporter Activity Symporter Activity Renal Water Transport Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Blood Pressure Sodium Ion Transport Protein Binding Connexin Complex Nitrate Transmembrane Transporter Activity Transmembrane Transport Water Transport Renal System Process System Process Renal Water Retention Positive Regulation Of Blood Pressure Bis(monoacylglycero)phosphate Synthase Activity Positive Regulation Of GTP Binding Vacuolar Lumen Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Metal Ion Transport Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Positive Regulation Of Acute Inflammatory Response Mucosal Immune Response Organ Or Tissue Specific Immune Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Ethanol Bile Acid And Bile Salt Transport
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