TBXA2R and ARL6IP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBXA2R	ARL6IP6
Description		thromboxane A2 receptor	ARF like GTPase 6 interacting protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck	Nucleus Nuclear Inner Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs		Ridogrel Seratrodast Morniflumate
Diseases
GWAS			Lung cancer ( 28604730) Pancreatic cancer ( 29422604) Recurrent major depressive disorder x sex interaction ( 34099189) Refractive error ( 32231278)
Interacting Genes		35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15	17 interacting genes: APP AQP6 ARL6 CLRN2 CMTM2 DRD2 EBP GJA8 GPR61 MGST3 RUSF1 SLC10A1 TBXA2R TIMMDC1 TMEM205 TMEM80 TMEM86B
Entrez ID		6915	151188
HPRD ID		01768	12485
Ensembl ID		ENSG00000006638	ENSG00000177917
Uniprot IDs		P21731 Q05C92 Q0VAB0	A0A8I5KQ30 B3KMZ5 Q8N6S5
PDB IDs		8XJN 8XJO
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH	Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?