TBXA2R and EMP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TBXA2R	EMP1
Name		thromboxane A2 receptor	epithelial membrane protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Apoptotic Process Epidermis Development Bleb Assembly
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor	None
Drugs		Ridogrel Seratrodast Morniflumate	None
GWAS		No GWAS studies recorded	Coronary artery calcification ( 23870195 ) Degraded stimulus continuous performance test score ( 31596458 ) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136 ) Heel bone mineral density ( 28869591 30598549 ) Household income (MTAG) ( 31844048 ) Refractive error ( 32231278 ) Serum albumin levels ( 29403010 )
Interacting Genes		35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15	61 interacting genes: ANK1 ANKS6 APOL2 AQP6 ARL13B ARL6IP1 ASGR2 ATP6V0B ATP6V0E1 BTN2A2 CATSPERH CCR5 CD37 CD3G CD53 CD79A CEP70 CLDN9 CORIN CXCR2 EBP EDA EHHADH ERGIC3 FFAR2 GIMAP5 GPR42 GPRC5D HTR2C ISLR2 JPH1 KLRC1 LAPTM4B LEPROTL1 LHFPL5 LPAR6 LRRC3B LSMEM2 MAL MALL MS4A7 OPRM1 PLEKHB2 PMP22 RABAC1 RPRM SERTM1 SMIM3 SPACA1 STOM SYNE4 TBXA2R TEX264 TLCD4 TMEM114 TMEM160 TMEM218 TMEM239 TMEM31 TMEM9 TSPO2
Entrez ID		6915	2012
HPRD ID		01768	11892
Ensembl ID		ENSG00000006638	ENSG00000134531
Uniprot IDs		P21731 Q05C92 Q0VAB0	P54849
PDB IDs		8XJN 8XJO	Not available
GO Terms Enriched among Interactors		Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH	Membrane Plasma Membrane Protein Binding G Protein-coupled Receptor Activity External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Multivesicular Body Membrane