TBX5 and NKX2-5

Number of citations of the paper that reports this interaction (PMID 11431700)
82

Data Source:
HPRD (in vivo, in vitro)

		TBX5	NKX2-5
Gene Name		T-box 5	NK2 homeobox 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of Execution Phase Of Apoptosis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Transcription From RNA Polymerase II Promoter Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation BMP Signaling Pathway Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Blood pressure ( 21909110) Diastolic blood pressure ( 19430479) Electrocardiographic traits ( 20062063) Mammographic density ( 22532574) Obesity-related traits ( 23251661) PR interval ( 20062060 23139255) Prostate cancer ( 23535732) Ventricular conduction ( 21076409) Visceral fat ( 22589738)	Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060)
Protein-Protein Interactions		4 interactors: GATA4 KAT5 KDM6A NKX2-5	13 interactors: CAMTA2 CSNK2A1 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		6910	1482
HPRD ID		03372	02787
Ensembl ID		ENSG00000089225	ENSG00000183072
Uniprot IDs		Q99593	P52952
PDB IDs		2X6U 2X6V	3RKQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardioblast Differentiation Canonical Wnt Signaling Pathway Septum Secundum Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Heart Morphogenesis Atrial Septum Development Wnt Signaling Pathway Cardiac Atrium Morphogenesis Embryonic Organ Morphogenesis Cardiac Muscle Tissue Growth Epithelial Tube Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Tube Morphogenesis Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Cardiac Septum Morphogenesis Regulation Of Heart Growth Pattern Specification Process Embryonic Organ Development Growth Regulation Of Cardiac Muscle Tissue Development Heart Looping Morphogenesis Of An Epithelium Determination Of Heart Left/right Asymmetry Heart Development Embryonic Heart Tube Morphogenesis Cardiac Muscle Cell Development Cardiac Ventricle Morphogenesis Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cardiac Septum Development Regulation Of Growth Embryonic Heart Tube Development Regulation Of Striated Muscle Contraction Embryonic Morphogenesis Tissue Morphogenesis Organ Growth Tube Development Regulation Of Organ Growth Cardiac Ventricle Development Determination Of Left/right Symmetry Cardiac Muscle Cell Differentiation Determination Of Bilateral Symmetry Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Lung Lobe Formation	Organ Morphogenesis Embryonic Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryonic Organ Morphogenesis Tissue Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Metabolic Process Embryo Development Anatomical Structure Morphogenesis Heart Morphogenesis Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Pattern Specification Process Anterior/posterior Pattern Specification Embryonic Organ Development Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cardiac Chamber Development Organ Development System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Muscle Tissue Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Growth Positive Regulation Of Cell Proliferation Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heart Development Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Aorta Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardiac Muscle Cell Proliferation Aorta Development Striated Muscle Tissue Development
Tagcloud ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts
Tagcloud (Difference) ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts
Tagcloud (Intersection) ?