TBX5 and NKX2-5

Number of citations of the paper that reports this interaction (PubMedID 11431700)
0

Data Source:
HPRD (in vitro, in vivo)

		TBX5	NKX2-5
Description		T-box transcription factor 5	NK2 homeobox 5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Fate Specification Morphogenesis Of An Epithelium Sinoatrial Node Development Bundle Of His Development Atrioventricular Bundle Cell Differentiation Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Gap Junction Assembly Positive Regulation Of Cardiac Conduction	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis
Drugs
Diseases		Holt-Oram syndrome	Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
GWAS		Airflow obstruction ( 22837378) Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21909110) Bone mineral density (total hip) ( 29883787) Brugada syndrome ( 35210625) Diastolic blood pressure ( 19430479 28135244 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) FEV1 ( 30804560) Hypertension ( 30487518) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Mean arterial pressure ( 30487518) Obesity-related traits ( 23251661) P wave duration ( 28794112) Peak expiratory flow ( 30804560) Pelvic organ prolapse ( 32184442) Percent mammographic density ( 22532574) PR interval ( 32439900 20062060 30046033 25035420 23139255 21347284) Prostate cancer ( 25939597 23535732) QRS duration ( 30012220 27577874 21076409) Receptive language ability ( 32635940) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Visceral fat ( 22589738)	Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060 30046033 32439900) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)
Interacting Genes		7 interacting genes: BAIAP2 FBXO25 GATA4 KAT5 KDM6A NKX2-5 ZMYND10	19 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10
Entrez ID		6910	1482
HPRD ID		03372	02787
Ensembl ID		ENSG00000089225	ENSG00000183072
Uniprot IDs		Q99593	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		2X6U 2X6V 4S0H 5BQD	3RKQ 4S0H 6WC2 6WC5
Enriched GO Terms of Interacting Partners?		Atrioventricular Node Development Atrial Septum Morphogenesis Aortic Valve Morphogenesis Cardiac Muscle Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Cardiac Muscle Tissue Development Heart Development Septum Secundum Development Cardiac Septum Development Nkx-2.5 Complex Cardiac Septum Morphogenesis Purkinje Myocyte Differentiation Mesenchyme Development Regulation Of Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Differentiation Cardiocyte Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Muscle Cell Apoptotic Process Heart Valve Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Dendritic Spine Cytoplasm Neuron Projection Branch Point Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Stem Cell Differentiation Regulation Of Cardiac Muscle Contraction Intracellular Glucose Homeostasis Muscle Cell Differentiation Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Regulation Of Striated Muscle Contraction Atrial Septum Secundum Morphogenesis Positive Regulation Of Organelle Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Epithelial Tube Morphogenesis Striated Muscle Tissue Development His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Proepicardium Development Positive Regulation Of Developmental Process Regulation Of System Process Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis	Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation
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