TBX5

Gene Name		T-box 5
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of Execution Phase Of Apoptosis
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Blood pressure ( 21909110) Diastolic blood pressure ( 19430479) Electrocardiographic traits ( 20062063) Mammographic density ( 22532574) Obesity-related traits ( 23251661) PR interval ( 20062060 23139255) Prostate cancer ( 23535732) Ventricular conduction ( 21076409) Visceral fat ( 22589738)
Protein-protein Interactions		4 interactors: GATA4 KAT5 KDM6A NKX2-5
Entrez ID		6910
HPRD ID		03372
Ensembl ID		ENSG00000089225
Uniprot IDs		Q99593
PDB IDs		2X6U 2X6V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardioblast Differentiation Canonical Wnt Signaling Pathway Septum Secundum Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Heart Morphogenesis Atrial Septum Development Wnt Signaling Pathway Cardiac Atrium Morphogenesis Embryonic Organ Morphogenesis Cardiac Muscle Tissue Growth Epithelial Tube Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Tube Morphogenesis Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Cardiac Septum Morphogenesis Regulation Of Heart Growth Pattern Specification Process Embryonic Organ Development Growth Regulation Of Cardiac Muscle Tissue Development Heart Looping Morphogenesis Of An Epithelium Determination Of Heart Left/right Asymmetry Heart Development Embryonic Heart Tube Morphogenesis Cardiac Muscle Cell Development Cardiac Ventricle Morphogenesis Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cardiac Septum Development Regulation Of Growth Embryonic Heart Tube Development Regulation Of Striated Muscle Contraction Embryonic Morphogenesis Tissue Morphogenesis Organ Growth Tube Development Regulation Of Organ Growth Cardiac Ventricle Development Determination Of Left/right Symmetry Cardiac Muscle Cell Differentiation Determination Of Bilateral Symmetry Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Lung Lobe Formation
Tagcloud ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts