TBX5 and GATA4

Number of citations of the paper that reports this interaction (PubMedID 35182466)
146

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		TBX5	GATA4
Description		T-box transcription factor 5	GATA binding protein 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Fate Specification Morphogenesis Of An Epithelium Sinoatrial Node Development Bundle Of His Development Atrioventricular Bundle Cell Differentiation Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Gap Junction Assembly Positive Regulation Of Cardiac Conduction	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Atrioventricular Node Development Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Endoderm Development Heart Development Male Gonad Development Response To Xenobiotic Stimulus Response To Mechanical Stimulus Anatomical Structure Morphogenesis Tissue Development Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Wound Healing Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Cardiac Muscle Cell Differentiation Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Transcriptional regulation of testis differentiation Cardiogenesis Formation of lateral plate mesoderm Formation of definitive endoderm Factors involved in megakaryocyte development and platelet production Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases		Holt-Oram syndrome	Atrial septal defect
GWAS		Airflow obstruction ( 22837378) Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21909110) Bone mineral density (total hip) ( 29883787) Brugada syndrome ( 35210625) Diastolic blood pressure ( 19430479 28135244 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) FEV1 ( 30804560) Hypertension ( 30487518) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Mean arterial pressure ( 30487518) Obesity-related traits ( 23251661) P wave duration ( 28794112) Peak expiratory flow ( 30804560) Pelvic organ prolapse ( 32184442) Percent mammographic density ( 22532574) PR interval ( 32439900 20062060 30046033 25035420 23139255 21347284) Prostate cancer ( 25939597 23535732) QRS duration ( 30012220 27577874 21076409) Receptive language ability ( 32635940) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Visceral fat ( 22589738)	A body shape index ( 34021172) Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 35210625) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Left ventricular global circumferential strain (MTAG) ( 33495596) Left ventricular global longitudinal strain (MTAG) ( 33495596) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28739976 28135244 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: BAIAP2 FBXO25 GATA4 KAT5 KDM6A NKX2-5 ZMYND10	26 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 PRKN PRPF19 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2
Entrez ID		6910	2626
HPRD ID		03372	08994
Ensembl ID		ENSG00000089225	ENSG00000136574
Uniprot IDs		Q99593	B3KUF4 B6DU75 P43694
PDB IDs		2X6U 2X6V 4S0H 5BQD	2M9W 8VG0 8VG1
Enriched GO Terms of Interacting Partners?		Atrioventricular Node Development Atrial Septum Morphogenesis Aortic Valve Morphogenesis Cardiac Muscle Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Cardiac Muscle Tissue Development Heart Development Septum Secundum Development Cardiac Septum Development Nkx-2.5 Complex Cardiac Septum Morphogenesis Purkinje Myocyte Differentiation Mesenchyme Development Regulation Of Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Differentiation Cardiocyte Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Muscle Cell Apoptotic Process Heart Valve Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Dendritic Spine Cytoplasm Neuron Projection Branch Point Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Stem Cell Differentiation Regulation Of Cardiac Muscle Contraction Intracellular Glucose Homeostasis Muscle Cell Differentiation Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Regulation Of Striated Muscle Contraction Atrial Septum Secundum Morphogenesis Positive Regulation Of Organelle Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Epithelial Tube Morphogenesis Striated Muscle Tissue Development His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Proepicardium Development Positive Regulation Of Developmental Process Regulation Of System Process Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis	Heart Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Animal Organ Development Regulation Of Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Regulation Of Metabolic Process Cell Development Hematopoietic Or Lymphoid Organ Development Animal Organ Morphogenesis Cell Differentiation Regulation Of Multicellular Organismal Development Negative Regulation Of Developmental Process Nucleus Cardiac Ventricle Formation DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Developmental Process Cardiac Chamber Formation Muscle Tissue Development Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Gland Development Learning Or Memory DNA-templated Transcription Transcription By RNA Polymerase II
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