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TBX5 and KDM6A
Number of citations of the paper that reports this interaction (PubMedID
22192413
)
56
Data Source:
BioGRID
(two hybrid)
TBX5
KDM6A
Description
T-box transcription factor 5
lysine demethylase 6A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Protein-containing Complex
Protein-DNA Complex
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
MLL3/4 Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Protein Binding
Oxidoreductase Activity
Chromatin DNA Binding
Histone Demethylase Activity
Metal Ion Binding
Dioxygenase Activity
Histone H3K27me2/H3K27me3 Demethylase Activity
Biological Process
Cell Fate Specification
Morphogenesis Of An Epithelium
Sinoatrial Node Development
Bundle Of His Development
Atrioventricular Bundle Cell Differentiation
Atrioventricular Valve Morphogenesis
Endocardial Cushion Development
Cardiac Left Ventricle Formation
Ventricular Cardiac Muscle Tissue Development
Ventricular Septum Development
Atrial Septum Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Cell-cell Signaling
Pattern Specification Process
Heart Development
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Epithelial To Mesenchymal Transition
Lung Development
Embryonic Limb Morphogenesis
Negative Regulation Of Cell Migration
Embryonic Forelimb Morphogenesis
Forelimb Morphogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cardioblast Differentiation
Cardiac Muscle Cell Differentiation
Cardiac Muscle Cell Proliferation
Pericardium Development
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Atrial Septum Morphogenesis
Atrioventricular Node Cell Development
Atrioventricular Node Cell Fate Commitment
Cell Migration Involved In Coronary Vasculogenesis
Positive Regulation Of Secondary Heart Field Cardioblast Proliferation
Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling
Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Positive Regulation Of Gap Junction Assembly
Positive Regulation Of Cardiac Conduction
Chromatin Organization
Chromatin Remodeling
Heart Development
Regulation Of Gene Expression
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Physiological factors
Cardiogenesis
HDMs demethylate histones
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Formation of WDR5-containing histone-modifying complexes
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Chromatin modifications during the maternal to zygotic transition (MZT)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
Holt-Oram syndrome
GWAS
Airflow obstruction (
22837378
)
Atrial fibrillation (
30061737
33990960
29892015
28416822
28416818
)
Barrett's esophagus or Esophageal adenocarcinoma (
27527254
)
Benign prostatic hyperplasia and lower urinary tract symptoms (
30410027
)
Blood pressure (
21909110
)
Bone mineral density (total hip) (
29883787
)
Brugada syndrome (
35210625
)
Diastolic blood pressure (
19430479
28135244
27618452
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Diverticular disease (
30177863
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
FEV1 (
30804560
)
Hypertension (
30487518
)
Laryngeal squamous cell carcinoma (
25194280
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Lung function in heavy smokers (low FEV1 vs high FEV1) (
26423011
)
Mean arterial pressure (
30487518
)
Obesity-related traits (
23251661
)
P wave duration (
28794112
)
Peak expiratory flow (
30804560
)
Pelvic organ prolapse (
32184442
)
Percent mammographic density (
22532574
)
PR interval (
32439900
20062060
30046033
25035420
23139255
21347284
)
Prostate cancer (
25939597
23535732
)
QRS duration (
30012220
27577874
21076409
)
Receptive language ability (
32635940
)
Smoking status (ever vs never smokers) (
30643258
)
Systolic blood pressure (
27618452
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Thrombin-activatable fibrinolysis inhibitor levels (
29378355
)
Visceral fat (
22589738
)
Interacting Genes
7 interacting genes:
BAIAP2
FBXO25
GATA4
KAT5
KDM6A
NKX2-5
ZMYND10
15 interacting genes:
CREBBP
GSC2
H3-4
H3C1
H3C14
HUNK
MEOX2
MTDH
NKX2-5
RSPH1
SMAD9
SRF
TBX5
TLE1
TSPYL2
Entrez ID
6910
7403
HPRD ID
03372
02131
Ensembl ID
ENSG00000089225
ENSG00000147050
Uniprot IDs
Q99593
A0A087X0R0
A0A6Q8PFK0
A0A804HJA2
B4E0L8
B7ZKN1
B7ZKN5
B7ZKN6
E1U0S6
F5H5V6
F5H6S1
F8W8R6
O15550
Q59HG3
PDB IDs
2X6U
2X6V
4S0H
5BQD
3AVR
3AVS
6FUK
6FUL
Enriched GO Terms of Interacting Partners
?
Atrioventricular Node Development
Atrial Septum Morphogenesis
Aortic Valve Morphogenesis
Cardiac Muscle Cell Differentiation
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cardiac Ventricle Morphogenesis
DNA-binding Transcription Activator Activity
Cardiac Muscle Tissue Development
Heart Development
Septum Secundum Development
Cardiac Septum Development
Nkx-2.5 Complex
Cardiac Septum Morphogenesis
Purkinje Myocyte Differentiation
Mesenchyme Development
Regulation Of Cardiac Muscle Cell Apoptotic Process
Striated Muscle Cell Differentiation
Cardiocyte Differentiation
Heart Looping
Embryonic Heart Tube Morphogenesis
Negative Regulation Of Muscle Cell Apoptotic Process
Heart Valve Morphogenesis
Cellular Response To Glucose Stimulus
Cellular Response To Carbohydrate Stimulus
Dendritic Spine Cytoplasm
Neuron Projection Branch Point
Histone H2AK5 Acetyltransferase Activity
Positive Regulation Of Motile Cilium Assembly
Regulation Of Stem Cell Differentiation
Regulation Of Cardiac Muscle Contraction
Intracellular Glucose Homeostasis
Muscle Cell Differentiation
Atrial Cardiac Muscle Cell Development
Atrioventricular Node Cell Fate Commitment
Regulation Of Striated Muscle Contraction
Atrial Septum Secundum Morphogenesis
Positive Regulation Of Organelle Organization
Peptide Butyryltransferase Activity
Peptide 2-hydroxyisobutyryltransferase Activity
Peptide Crotonyltransferase Activity
Epithelial Tube Morphogenesis
Striated Muscle Tissue Development
His-Purkinje System Cell Differentiation
Pulmonary Myocardium Development
Proepicardium Development
Positive Regulation Of Developmental Process
Regulation Of System Process
Ventricular Cardiac Myofibril Assembly
Right Ventricular Cardiac Muscle Tissue Morphogenesis
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromatin
Atrioventricular Node Cell Fate Commitment
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
His-Purkinje System Cell Differentiation
Regulation Of RNA Metabolic Process
Positive Regulation Of Cardioblast Differentiation
Atrioventricular Node Cell Development
Bundle Of His Development
Transcription Regulator Complex
Nucleosome Assembly
DNA-binding Transcription Factor Activity
DNA Binding
Sequence-specific DNA Binding
Regulation Of DNA-templated Transcription
Chromatin Binding
Regulation Of RNA Biosynthetic Process
Nucleosome Organization
Cardiocyte Differentiation
Muscle Tissue Development
Cardiac Muscle Cell Fate Commitment
Cardiac Ventricle Formation
Atrial Septum Development
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Cardiac Chamber Formation
Protein-DNA Complex Assembly
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Atrial Cardiac Muscle Tissue Development
Ventricular Cardiac Muscle Tissue Development
Regulation Of Primary Metabolic Process
Muscle Cell Fate Commitment
Heart Trabecula Formation
Positive Regulation Of Cardiocyte Differentiation
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Cardiac Myofibril Assembly
Structural Constituent Of Chromatin
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Atrial Septum Morphogenesis
Epithelium Development
Positive Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
Regulation Of Metabolic Process
Cellular Component Assembly
Muscle Cell Differentiation
Positive Regulation Of Stem Cell Differentiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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