TBX2 and NKX2-5

Number of citations: 58 (PubMedID 12023302)
Data Source: HPRD (in vitro)

		TBX2	NKX2-5
Name		T-box transcription factor 2	NK2 homeobox 5
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Muscle Cell Fate Determination Regulation Of Heart Contraction Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Response To Retinoic Acid Embryonic Heart Tube Development Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Pigment Metabolic Process Involved In Pigmentation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation Roof Of Mouth Development Pharyngeal System Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Developmental Growth Involved In Morphogenesis Mammary Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Cellular Response To Dexamethasone Stimulus Ureteric Peristalsis Cochlea Morphogenesis Cellular Senescence Melanocyte Proliferation Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation Positive Regulation Of Cell Cycle G1/S Phase Transition Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis
Diseases		None	Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
GWAS		Age-related hearing impairment ( 34108613 ) Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Chloride levels ( 29403010 ) Chronic kidney disease ( 20383146 ) Circulating fibroblast growth factor 23 levels ( 30217807 ) Corneal hysteresis ( 32716492 ) Corneal resistance factor ( 32716492 ) Coronary artery disease ( 29212778 ) Creatinine levels ( 31015462 20383145 ) Diastolic blood pressure ( 30487518 27618448 27618447 27841878 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 19893584 18391951 20881960 ) Hypertension ( 30487518 27618447 ) Kidney volume ( 34128465 ) Mean arterial pressure ( 27618448 30487518 26390057 ) Potassium levels ( 29403010 ) Pulse pressure ( 27841878 27618447 ) Refractive error ( 32231278 ) Sitting height ratio ( 25865494 ) Spontaneous preterm birth without premature rupture of membranes ( 31194736 ) Systolic blood pressure ( 30487518 28739976 27618447 27618448 27841878 ) Waist circumference adjusted for body mass index ( 34021172 )	Atrial fibrillation ( 29892015 30061737 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heart rate ( 23583979 ) Infantile hypertrophic pyloric stenosis ( 22306654 ) PR interval ( 20062060 30046033 32439900 ) Resting heart rate ( 27798624 ) Stroke ( 26089329 ) TPE interval (resting) ( 32386560 )
Novel Interactors		None recorded	1 novel interactors: FLT4
Interacting Genes		12 interacting genes: ATXN1L CEBPE CIDEB CNOT2 CYSRT1 KRTAP6-3 LMO2 LZTR1 MEIS2 NKX2-5 TNPO2 TTC19	19 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10
Entrez ID		6909	1482
HPRD ID		02850	02787
Ensembl ID		ENSG00000121068	ENSG00000183072
Uniprot IDs		Q13207	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		Not available	3RKQ 4S0H 6WC2 6WC5
GO Terms Enriched among Interactors		None	Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation