TBX2 and NKX2-5

Number of citations of the paper that reports this interaction (PMID 12023302)
59

Data Source:
HPRD (in vitro)

		TBX2	NKX2-5
Gene Name		T-box 2	NK2 homeobox 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription, DNA-templated Muscle Cell Fate Determination Cell Aging Positive Regulation Of Cell Proliferation Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Negative Regulation Of Transcription, DNA-templated Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Palate Development Positive Regulation Of Cardiac Muscle Cell Proliferation Pharynx Development Developmental Growth Involved In Morphogenesis Mammary Placode Formation Cellular Senescence Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Transcription From RNA Polymerase II Promoter Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation BMP Signaling Pathway Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Height ( 20881960 19893584 18391951)	Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060)
Protein-Protein Interactions		3 interactors: CEBPE LZTR1 NKX2-5	13 interactors: CAMTA2 CSNK2A1 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		6909	1482
HPRD ID		02850	02787
Ensembl ID		ENSG00000121068	ENSG00000183072
Uniprot IDs		Q13207	P52952
PDB IDs			3RKQ
Enriched GO Terms of Interacting Partners?		Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrioventricular Node Cell Development Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Positive Regulation Of Voltage-gated Calcium Channel Activity Proepicardium Development Pulmonary Myocardium Development Bundle Of His Development Atrial Cardiac Muscle Cell Development Embryonic Heart Tube Left/right Pattern Formation Septum Secundum Development Cardiac Muscle Cell Fate Commitment Ventricular Cardiac Myofibril Assembly Positive Regulation Of Cardioblast Differentiation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Formation Negative Regulation Of Myotube Differentiation Cardiac Chamber Formation Ventricular Trabecula Myocardium Morphogenesis Cardiac Conduction System Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Striated Muscle Cell Apoptotic Process Outflow Tract Septum Morphogenesis Hemopoiesis Heart Trabecula Formation Adult Heart Development Positive Regulation Of DNA-templated Transcription, Initiation Muscle Cell Fate Commitment Venous Blood Vessel Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Macrophage Differentiation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Voltage-gated Calcium Channel Activity Immune System Development Atrial Septum Development Pharyngeal System Development Left/right Pattern Formation Regulation Of DNA-templated Transcription, Initiation Cardiac Myofibril Assembly Cardiac Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cytokine Biosynthetic Process Apoptotic Process Involved In Morphogenesis Thyroid Gland Development Heart Trabecula Morphogenesis	Organ Morphogenesis Embryonic Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryonic Organ Morphogenesis Tissue Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Metabolic Process Embryo Development Anatomical Structure Morphogenesis Heart Morphogenesis Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Pattern Specification Process Anterior/posterior Pattern Specification Embryonic Organ Development Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cardiac Chamber Development Organ Development System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Muscle Tissue Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Growth Positive Regulation Of Cell Proliferation Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heart Development Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Aorta Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardiac Muscle Cell Proliferation Aorta Development Striated Muscle Tissue Development
Tagcloud ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 nppa pluripotency pluripotent reconstitute reprogrammed signatures sre tnnt2
Tagcloud (Difference) ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 nppa pluripotency pluripotent reconstitute reprogrammed signatures sre tnnt2
Tagcloud (Intersection) ?