TBX2 and CEBPE

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TBX2	CEBPE
Gene Name		T-box 2	CCAAT/enhancer binding protein (C/EBP), epsilon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription, DNA-templated Muscle Cell Fate Determination Cell Aging Positive Regulation Of Cell Proliferation Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Negative Regulation Of Transcription, DNA-templated Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Palate Development Positive Regulation Of Cardiac Muscle Cell Proliferation Pharynx Development Developmental Growth Involved In Morphogenesis Mammary Placode Formation Cellular Senescence Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation	Transcription, DNA-templated Phagocytosis Defense Response Macrophage Differentiation Cytokine Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Height ( 20881960 19893584 18391951)	Acute lymphoblastic leukemia (childhood) ( 23512250 19684604)
Protein-Protein Interactions		3 interactors: CEBPE LZTR1 NKX2-5	44 interactors: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TCEB2 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		6909	1053
HPRD ID		02850	02852
Ensembl ID		ENSG00000121068	ENSG00000092067
Uniprot IDs		Q13207	Q15744
PDB IDs			3T92
Enriched GO Terms of Interacting Partners?		Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrioventricular Node Cell Development Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Positive Regulation Of Voltage-gated Calcium Channel Activity Proepicardium Development Pulmonary Myocardium Development Bundle Of His Development Atrial Cardiac Muscle Cell Development Embryonic Heart Tube Left/right Pattern Formation Septum Secundum Development Cardiac Muscle Cell Fate Commitment Ventricular Cardiac Myofibril Assembly Positive Regulation Of Cardioblast Differentiation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Formation Negative Regulation Of Myotube Differentiation Cardiac Chamber Formation Ventricular Trabecula Myocardium Morphogenesis Cardiac Conduction System Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Striated Muscle Cell Apoptotic Process Outflow Tract Septum Morphogenesis Hemopoiesis Heart Trabecula Formation Adult Heart Development Positive Regulation Of DNA-templated Transcription, Initiation Muscle Cell Fate Commitment Venous Blood Vessel Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Macrophage Differentiation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Voltage-gated Calcium Channel Activity Immune System Development Atrial Septum Development Pharyngeal System Development Left/right Pattern Formation Regulation Of DNA-templated Transcription, Initiation Cardiac Myofibril Assembly Cardiac Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cytokine Biosynthetic Process Apoptotic Process Involved In Morphogenesis Thyroid Gland Development Heart Trabecula Morphogenesis	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cellular Process Myeloid Cell Differentiation Hemopoiesis Myeloid Leukocyte Differentiation Cellular Metabolic Process Immune System Development Negative Regulation Of Cellular Metabolic Process Organ Development Dendritic Cell Differentiation Anatomical Structure Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity System Development Myeloid Dendritic Cell Differentiation Leukocyte Activation Myeloid Dendritic Cell Activation
Tagcloud ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 nppa pluripotency pluripotent reconstitute reprogrammed signatures sre tnnt2	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned
Tagcloud (Difference) ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 nppa pluripotency pluripotent reconstitute reprogrammed signatures sre tnnt2	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned
Tagcloud (Intersection) ?