TBX2 and LZTR1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TBX2	LZTR1
Gene Name		T-box 2	leucine-zipper-like transcription regulator 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Protein Binding Sequence-specific DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription, DNA-templated Muscle Cell Fate Determination Cell Aging Positive Regulation Of Cell Proliferation Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Negative Regulation Of Transcription, DNA-templated Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Palate Development Positive Regulation Of Cardiac Muscle Cell Proliferation Pharynx Development Developmental Growth Involved In Morphogenesis Mammary Placode Formation Cellular Senescence Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Height ( 20881960 19893584 18391951)
Protein-Protein Interactions		3 interactors: CEBPE LZTR1 NKX2-5	50 interactors: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 IKBKG KDM2B L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		6909	8216
HPRD ID		02850	08992
Ensembl ID		ENSG00000121068	ENSG00000099949
Uniprot IDs		Q13207	Q8N653
PDB IDs
Enriched GO Terms of Interacting Partners?		Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrioventricular Node Cell Development Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Positive Regulation Of Voltage-gated Calcium Channel Activity Proepicardium Development Pulmonary Myocardium Development Bundle Of His Development Atrial Cardiac Muscle Cell Development Embryonic Heart Tube Left/right Pattern Formation Septum Secundum Development Cardiac Muscle Cell Fate Commitment Ventricular Cardiac Myofibril Assembly Positive Regulation Of Cardioblast Differentiation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Formation Negative Regulation Of Myotube Differentiation Cardiac Chamber Formation Ventricular Trabecula Myocardium Morphogenesis Cardiac Conduction System Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Striated Muscle Cell Apoptotic Process Outflow Tract Septum Morphogenesis Hemopoiesis Heart Trabecula Formation Adult Heart Development Positive Regulation Of DNA-templated Transcription, Initiation Muscle Cell Fate Commitment Venous Blood Vessel Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Macrophage Differentiation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Voltage-gated Calcium Channel Activity Immune System Development Atrial Septum Development Pharyngeal System Development Left/right Pattern Formation Regulation Of DNA-templated Transcription, Initiation Cardiac Myofibril Assembly Cardiac Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cytokine Biosynthetic Process Apoptotic Process Involved In Morphogenesis Thyroid Gland Development Heart Trabecula Morphogenesis	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Chromatin Organization Viral Process Negative Regulation Of Cellular Metabolic Process Cellular Process Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Chromatin Modification DNA-templated Transcription, Elongation Chromatin Remodeling Positive Regulation Of Viral Transcription
Tagcloud ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 nppa pluripotency pluripotent reconstitute reprogrammed signatures sre tnnt2
Tagcloud (Difference) ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 nppa pluripotency pluripotent reconstitute reprogrammed signatures sre tnnt2
Tagcloud (Intersection) ?