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TAP2 and HLA-G
Number of citations of the paper that reports this interaction (PMID
9103419
)
4
Data Source:
HPRD
(in vivo)
TAP2
HLA-G
Gene Name
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
major histocompatibility complex, class I, G
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
TAP Complex
Golgi Membrane
Plasma Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Transporter Activity
Protein Binding
ATP Binding
Peptide Transporter Activity
Peptide Antigen-transporting ATPase Activity
MHC Class Ib Protein Binding
TAP1 Binding
Tapasin Binding
Receptor Binding
Peptide Antigen Binding
Protein Homodimerization Activity
Biological Process
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent
Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Metabolic Process
Intracellular Transport Of Viral Protein In Host Cell
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Cytosol To ER Transport
Peptide Antigen Transport
Transmembrane Transport
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Tolerance Induction
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Cellular Defense Response
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-12 Production
Negative Regulation Of T Cell Proliferation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Negative Regulation Of Dendritic Cell Differentiation
Pathways
Class I MHC mediated antigen processing & presentation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Lymphoma (
23349640
)
Nephropathy (
21399633
)
Pubertal anthropometrics (
23449627
)
Crohn's disease (
22412388
)
IgE levels (
22075330
)
Rheumatoid arthritis (
21653640
)
Protein-Protein Interactions
9 interactors:
APP
HLA-C
HLA-G
PSMB5
PSMB8
PSMG3
RBM18
TAP1
TAPBP
9 interactors:
B2M
CD8A
COPB1
KIR2DL4
KLRD1
LILRB1
LILRB2
TAP1
TAP2
Entrez ID
6891
3135
HPRD ID
01360
00834
Ensembl ID
ENSG00000204267
ENSG00000204632
Uniprot IDs
Q03519
Q9UP03
P17693
Q29897
Q31611
Q5RJ85
Q6DU14
PDB IDs
1YDP
2D31
2DYP
3BZE
3CDG
3CII
3KYN
3KYO
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Antigen
Immune System Process
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Response To Type I Interferon
Viral Process
Immune Response
Defense Response
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Innate Immune Response
Positive Regulation Of Cell Cycle
Response To Stress
Positive Regulation Of Proteolysis
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cellular Amino Acid Metabolic Process
Regulation Of Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of T Cell Mediated Cytotoxicity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Cytokine-mediated Signaling Pathway
Positive Regulation Of Ligase Activity
Regulation Of T Cell Mediated Cytotoxicity
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Regulation Of Cell Cycle Process
Regulation Of Ubiquitin-protein Transferase Activity
Peptide Antigen Stabilization
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Immune System Process
Defense Response
Cytosol To ER Transport
Regulation Of Immune Response
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Fc Receptor Mediated Inhibitory Signaling Pathway
Intracellular Transport Of Viral Protein In Host Cell
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-inhibiting Signal Transduction
Antigen Processing And Presentation
Regulation Of Dendritic Cell Differentiation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Single Organismal Cell-cell Adhesion
Viral Process
Response To Stress
Intracellular Transport Of Virus
Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Response To Other Organism
Response To Biotic Stimulus
Negative Regulation Of Calcium Ion Transport
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Cellular Defense Response
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Positive Regulation Of Immune System Process
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Cytotoxic T Cell Differentiation
Negative Regulation Of Interferon-beta Secretion
Lymphocyte Activation
Regulation Of Defense Response To Virus
Regulation Of T Cell Mediated Cytotoxicity
Peptide Transport
Negative Regulation Of Ion Transport
Tagcloud
?
beta2
blocker
chains
clamp
class
confocal
detectable
dissociated
drastically
electric
electrophysiological
electrophysiology
exceptions
heavy
ifn
mhc
microglobulin
neurons
neurotransmitter
partly
patch
reverted
tap1
tetrodotoxin
transcribe
transcribed
transporters
upregulate
Tagcloud (Difference)
?
beta2
blocker
chains
clamp
class
confocal
detectable
dissociated
drastically
electric
electrophysiological
electrophysiology
exceptions
heavy
ifn
mhc
microglobulin
neurons
neurotransmitter
partly
patch
reverted
tap1
tetrodotoxin
transcribe
transcribed
transporters
upregulate
Tagcloud (Intersection)
?