TAP2 and PSMB5

Number of citations of the paper that reports this interaction (PubMedID 15488952)
0

Data Source:
HPRD (two hybrid)

		TAP2	PSMB5
Description		transporter 2, ATP binding cassette subfamily B member	proteasome 20S subunit beta 5
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport	Proteolysis Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly Proteolysis Involved In Protein Catabolic Process
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs			Bortezomib (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Nephropathy ( 21399633) Platelet distribution width ( 32888494) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for body mass index ( 34021172)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		10 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1	28 interacting genes: ABCB5 BAG4 CCDC150 CLP1 DUSP29 GAGE12G GAGE2E IKBKG LSM1 NTAQ1 PIK3R1 PLK1 POMP PRNP PSMA1 PSMA2 PSMA3 PSMB1 PSMB3 PSMB4 PSMB7 PSMG3 TAP1 TAP2 TCHP TRAF6 UBD XRN1
Entrez ID		6891	5693
HPRD ID		01360	02629
Ensembl ID		ENSG00000204267	ENSG00000100804
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5	A0A140VJS7 P28074
PDB IDs		5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5L5W 5L5X 5L5Y 5L5Z 5L60 5L61 5L62 5L63 5L64 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8QYN 8QYO 8QYS 8QZ9 8TM6 8UD9 8YIX 8YIY 8YIZ 9E8G 9E8O 9E8Q 9HMN
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle	Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Beta-subunit Complex Proteasome Core Complex, Alpha-subunit Complex Cytosol Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex Macromolecule Catabolic Process ABC-type Peptide Transporter Activity Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process TAP1 Binding Cytosol To Endoplasmic Reticulum Transport MHC Class Ib Protein Binding ABC-type Transporter Activity Protein Catabolic Process MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Protein Localization To Cell Periphery Antigen Processing And Presentation Of Peptide Antigen Proteasome Assembly Cytoplasm Histone MRNA Catabolic Process Proteolysis P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Myeloid Dendritic Cell Differentiation Antigen Processing And Presentation Catabolic Process Regulation Of Immune Response Histone MRNA Metabolic Process Myeloid Dendritic Cell Activation Nucleus Secretory Granule Lumen Antigen Processing And Presentation Of Endogenous Antigen Ficolin-1-rich Granule Lumen Protein Metabolic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Macromolecule Metabolic Process Type 8 Metabotropic Glutamate Receptor Binding Lipopolysaccharide Binding Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?