TAP2 and RBM18

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TAP2	RBM18
Description		transporter 2, ATP binding cassette subfamily B member	RNA binding motif protein 18
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex	Nucleoplasm Cytosol Intercellular Bridge
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Nucleic Acid Binding RNA Binding
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Nephropathy ( 21399633) Platelet distribution width ( 32888494) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1	5 interacting genes: CLTRN EPHA3 GCNT3 NDUFAB1 TAP2
Entrez ID		6891	92400
HPRD ID		01360	15224
Ensembl ID		ENSG00000204267	ENSG00000119446
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5	Q96H35
PDB IDs		5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle	Fasciculation Of Motor Neuron Axon Acyl Binding Acyl Carrier Activity Tapasin Binding ABC-type Peptide Antigen Transporter Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Peptide Transmembrane Transporter Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Transport TAP Complex Acetylgalactosaminyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity N-acetyllactosaminide Beta-1,6-N-acetylglucosaminyltransferase Activity Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity Positive Regulation Of L-proline Import Across Plasma Membrane Amide Transport Fasciculation Of Sensory Neuron Axon Mitochondrial Large Ribosomal Subunit Binding Peptide Antigen Transport ABC-type Peptide Transporter Activity Mitochondrial [2Fe-2S] Assembly Complex Protein Lipoylation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Cytosol To Endoplasmic Reticulum Transport MHC Class Ib Protein Binding GPI-linked Ephrin Receptor Activity MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex Transporter Activator Activity Insulin Secretion Involved In Cellular Response To Glucose Stimulus SNARE Complex Assembly Ephrin Receptor Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Kidney Morphogenesis Transmembrane-ephrin Receptor Activity T Cell Mediated Cytotoxicity UDP-glycosyltransferase Activity Acetylglucosaminyltransferase Activity Axonal Fasciculation Neuron Projection Fasciculation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Amino Acid Transport Carbohydrate Derivative Biosynthetic Process Iron-sulfur Cluster Assembly Protein Modification Process Antigen Processing And Presentation Of Endogenous Antigen
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