HLA-G and LILRB1

Number of citations of the paper that reports this interaction (PMID 12853576)
72

Data Source:
HPRD (in vivo, in vitro)

		HLA-G	LILRB1
Gene Name		major histocompatibility complex, class I, G	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding Protein Homodimerization Activity	Protein Phosphatase 1 Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cellular Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Negative Regulation Of Dendritic Cell Differentiation	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Interferon-beta Secretion Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interferon-gamma Secretion Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of Osteoclast Development
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) IgE levels ( 22075330) Rheumatoid arthritis ( 21653640)
Protein-Protein Interactions		9 interactors: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2	6 interactors: B2M HLA-A HLA-B HLA-C HLA-F HLA-G
Entrez ID		3135	10859
HPRD ID		00834	07273
Ensembl ID		ENSG00000204632	ENSG00000104972
Uniprot IDs		P17693 Q29897 Q31611 Q5RJ85 Q6DU14	A8MVE2 Q8NHL6
PDB IDs		1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO	1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Defense Response Cytosol To ER Transport Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Single Organismal Cell-cell Adhesion Viral Process Response To Stress Intracellular Transport Of Virus Immune Response Antigen Processing And Presentation Of Peptide Antigen Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Calcium Ion Transport T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cellular Defense Response Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Cytotoxic T Cell Differentiation Negative Regulation Of Interferon-beta Secretion Lymphocyte Activation Regulation Of Defense Response To Virus Regulation Of T Cell Mediated Cytotoxicity Peptide Transport Negative Regulation Of Ion Transport	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Response To Interferon-gamma Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Cytokine Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Immune Response Regulation Of Immune System Process Defense Response Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Response To Organic Substance Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Immune System Process Response To Organic Substance Regulation Of Dendritic Cell Differentiation Viral Process Cell Surface Receptor Signaling Pathway Response To Stress Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Detection Of Biotic Stimulus Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Regulation Of Interleukin-12 Production
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