HLA-G and TAP1

Number of citations of the paper that reports this interaction (PMID 9103419)
4

Data Source:
HPRD (in vivo)

		HLA-G	TAP1
Gene Name		major histocompatibility complex, class I, G	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex
	Molecular Function	Receptor Binding Peptide Antigen Binding Protein Homodimerization Activity	Protein Binding ATP Binding Peptide Transporter Activity Peptide-transporting ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cellular Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Negative Regulation Of Dendritic Cell Differentiation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Metabolic Process Peptide Transport Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Transmembrane Transport
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) IgE levels ( 22075330) Rheumatoid arthritis ( 21653640)	Nephropathy ( 21399633)
Protein-Protein Interactions		9 interactors: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2	12 interactors: ESR1 HLA-F HLA-G KRTAP4-12 MDFI MUL1 PDIA3 PSMB5 PSMB8 TAP2 TAPBP TDP2
Entrez ID		3135	6890
HPRD ID		00834	01359
Ensembl ID		ENSG00000204632	ENSG00000168394
Uniprot IDs		P17693 Q29897 Q31611 Q5RJ85 Q6DU14	F5H648 Q03518
PDB IDs		1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO	1JJ7
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Defense Response Cytosol To ER Transport Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Single Organismal Cell-cell Adhesion Viral Process Response To Stress Intracellular Transport Of Virus Immune Response Antigen Processing And Presentation Of Peptide Antigen Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Calcium Ion Transport T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cellular Defense Response Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Cytotoxic T Cell Differentiation Negative Regulation Of Interferon-beta Secretion Lymphocyte Activation Regulation Of Defense Response To Virus Regulation Of T Cell Mediated Cytotoxicity Peptide Transport Negative Regulation Of Ion Transport	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Positive Regulation Of Signal Transduction Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Stress Cellular Response To Stress Signal Transduction Negative Regulation Of Signal Transduction Signaling Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Negative Regulation Of Signaling Activation Of JUN Kinase Activity Response To Stimulus Regulation Of Apoptotic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Stimulus Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Death Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of JUN Kinase Activity Peptide Antigen Stabilization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Modification Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of JUN Kinase Activity
Tagcloud ?			activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk
Tagcloud (Difference) ?			activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk
Tagcloud (Intersection) ?