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HLA-G and CD8A
Number of citations of the paper that reports this interaction (PMID
10843658
)
41
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
HLA-G
CD8A
Gene Name
major histocompatibility complex, class I, G
CD8a molecule
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Plasma Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
T Cell Receptor Complex
Molecular Function
Receptor Binding
Peptide Antigen Binding
Protein Homodimerization Activity
Protein Binding
Coreceptor Activity
Protein Kinase Binding
MHC Class I Protein Binding
Protein Homodimerization Activity
Biological Process
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Tolerance Induction
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Cellular Defense Response
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-12 Production
Negative Regulation Of T Cell Proliferation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Negative Regulation Of Dendritic Cell Differentiation
T Cell Mediated Immunity
Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Antigen Processing And Presentation
T Cell Activation
Cytotoxic T Cell Differentiation
Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
Defense Response To Virus
Pathways
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Drugs
Diseases
GWAS
Crohn's disease (
22412388
)
IgE levels (
22075330
)
Rheumatoid arthritis (
21653640
)
Protein-Protein Interactions
9 interactors:
B2M
CD8A
COPB1
KIR2DL4
KLRD1
LILRB1
LILRB2
TAP1
TAP2
17 interactors:
B2M
CACYBP
CD3D
CD59
CD8B
CDK1
HLA-A
HLA-B
HLA-C
HLA-E
HLA-G
LAT
LCK
LGALS1
PTPRC
SREK1
SRSF1
Entrez ID
3135
925
HPRD ID
00834
01737
Ensembl ID
ENSG00000204632
ENSG00000153563
Uniprot IDs
P17693
Q29897
Q31611
Q5RJ85
Q6DU14
P01732
Q6ZVS2
Q8TAW8
PDB IDs
1YDP
2D31
2DYP
3BZE
3CDG
3CII
3KYN
3KYO
1AKJ
1CD8
1Q69
2HP4
3QZW
Enriched GO Terms of Interacting Partners
?
Regulation Of Immune System Process
Defense Response
Cytosol To ER Transport
Regulation Of Immune Response
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Fc Receptor Mediated Inhibitory Signaling Pathway
Intracellular Transport Of Viral Protein In Host Cell
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-inhibiting Signal Transduction
Antigen Processing And Presentation
Regulation Of Dendritic Cell Differentiation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Single Organismal Cell-cell Adhesion
Viral Process
Response To Stress
Intracellular Transport Of Virus
Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Response To Other Organism
Response To Biotic Stimulus
Negative Regulation Of Calcium Ion Transport
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Cellular Defense Response
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Positive Regulation Of Immune System Process
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Cytotoxic T Cell Differentiation
Negative Regulation Of Interferon-beta Secretion
Lymphocyte Activation
Regulation Of Defense Response To Virus
Regulation Of T Cell Mediated Cytotoxicity
Peptide Transport
Negative Regulation Of Ion Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Regulation Of Immune System Process
Positive Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cell Killing
Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of Immune Response
Positive Regulation Of Adaptive Immune Response
Immune System Process
Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Interferon-gamma-mediated Signaling Pathway
Regulation Of T Cell Activation
Innate Immune Response
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Cellular Response To Interferon-gamma
Positive Regulation Of T Cell Activation
Regulation Of Cell-cell Adhesion
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Defense Response
Response To Interferon-gamma
Antigen Processing And Presentation Of Endogenous Antigen
Positive Regulation Of Cell-cell Adhesion
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Protection From Natural Killer Cell Mediated Cytotoxicity
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Regulation Of Cell Activation
Response To Type I Interferon
Positive Regulation Of Cell Activation
Antigen Processing And Presentation Of Peptide Antigen
Regulation Of Defense Response To Virus By Virus
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Antigen Processing And Presentation
Cell Activation
Negative Regulation Of Immune Response
Leukocyte Activation
T Cell Aggregation
T Cell Activation
Tagcloud
?
anthracycline
assignment
bcs
carboplatin
cb
ccl5
cd21
cd80
ctla4
cxcl13
cxcl9
foxp3
geparsixto
hierarchic
histopathologic
ido1
igkc
immunogenicity
immunologic
immunologically
infiltrating
lpbc
ors
pmcb
standardization
taxane
tils
tn
univariable
Tagcloud (Difference)
?
anthracycline
assignment
bcs
carboplatin
cb
ccl5
cd21
cd80
ctla4
cxcl13
cxcl9
foxp3
geparsixto
hierarchic
histopathologic
ido1
igkc
immunogenicity
immunologic
immunologically
infiltrating
lpbc
ors
pmcb
standardization
taxane
tils
tn
univariable
Tagcloud (Intersection)
?