TAP2 and PSMB8

Number of citations of the paper that reports this interaction (PMID 15488952)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TAP2	PSMB8
Gene Name		transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	proteasome (prosome, macropain) subunit, beta type, 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex	Proteasome Complex Nucleoplasm Cytosol Proteasome Core Complex Extracellular Vesicular Exosome Spermatoproteasome Complex
	Molecular Function	Transporter Activity Protein Binding ATP Binding Peptide Transporter Activity Peptide Antigen-transporting ATPase Activity MHC Class Ib Protein Binding TAP1 Binding Tapasin Binding	Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Metabolic Process Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Peptide Antigen Transport Transmembrane Transport	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Cytokine-mediated Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Fat Cell Differentiation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Type I Interferon Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA Interferon Signaling M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cytokine Signaling in Immune system Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS		Lymphoma ( 23349640) Nephropathy ( 21399633) Pubertal anthropometrics ( 23449627)	Nephropathy ( 21399633)
Protein-Protein Interactions		9 interactors: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP	9 interactors: ABCB1 LSM1 POMP PSMA6 PSMB10 PSMB3 PSMB9 TAP1 TAP2
Entrez ID		6891	5696
HPRD ID		01360	01515
Ensembl ID		ENSG00000204267	ENSG00000204264
Uniprot IDs		Q03519 Q9UP03	P28062
PDB IDs
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Viral Process Immune Response Defense Response Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Innate Immune Response Positive Regulation Of Cell Cycle Response To Stress Positive Regulation Of Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of T Cell Mediated Cytotoxicity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Cytokine-mediated Signaling Pathway Positive Regulation Of Ligase Activity Regulation Of T Cell Mediated Cytotoxicity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Peptide Antigen Stabilization Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Viral Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Cytosol To ER Transport Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Ubiquitination
Tagcloud ?		beta2 blocker chains clamp class confocal detectable dissociated drastically electric electrophysiological electrophysiology exceptions heavy ifn mhc microglobulin neurons neurotransmitter partly patch reverted tap1 tetrodotoxin transcribe transcribed transporters upregulate
Tagcloud (Difference) ?		beta2 blocker chains clamp class confocal detectable dissociated drastically electric electrophysiological electrophysiology exceptions heavy ifn mhc microglobulin neurons neurotransmitter partly patch reverted tap1 tetrodotoxin transcribe transcribed transporters upregulate
Tagcloud (Intersection) ?