TAP2 and HLA-C

Number of citations: 0 (PubMedID 9551969)
Data Source: HPRD (in vivo)

		TAP2	HLA-C
Name		transporter 2, ATP binding cassette subfamily B member	major histocompatibility complex, class I, C
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Peptide Antigen Binding TAP Binding Receptor Ligand Activity
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Signal Transduction Antigen Processing And Presentation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1	None
GWAS		Asthma ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Composite immunoglobulin trait (IgA/IgG) ( 28628107 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Lymphocyte count ( 32888494 ) Lymphoma ( 23349640 ) Nephropathy ( 21399633 ) Platelet distribution width ( 32888494 ) Pubertal anthropometrics ( 23449627 ) Response to hepatitis B vaccine ( 29534301 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Urate levels in lean individuals ( 25811787 ) Waist circumference adjusted for body mass index ( 34021172 )	A body shape index ( 34021172 ) AIDS progression ( 19115949 ) Albumin-globulin ratio ( 29403010 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 23817571 ) Asthma ( 27182965 31619474 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 31619474 ) Asthma and major depressive disorder ( 31619474 ) Atopic dermatitis ( 23042114 25574825 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Basal cell carcinoma ( 33549134 ) Basophil count ( 32888494 ) Beta-2 microglubulin plasma levels ( 23417110 ) Birth weight ( 31043758 ) Blood cell traits (multivariate analysis) ( 31080455 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cancer ( 27197191 ) Cancer (pleiotropy) ( 27197191 ) Cervical cancer ( 28806749 ) Chickenpox ( 28928442 ) Childhood ear infection ( 27182965 28928442 ) Cholesterol, total ( 26582766 ) Chronic hepatitis B infection ( 25802187 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Cold sores ( 28928442 ) Complement C3 and C4 levels ( 23028341 ) Coronary heart disease ( 22319020 ) Crohn's disease ( 23128233 26891255 ) Cutaneous psoriasis ( 26626624 ) Decline in glucose metabolism in posterior cingulate cortex ( 29130521 ) Drug-induced liver injury (flucloxacillin) ( 30661239 ) Eosinophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling nervous ( 29500382 ) Feeling worry ( 29500382 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Height ( 23563607 25282103 31562340 ) Hematuria ( 30476138 ) Hematuria (mild) ( 30476138 ) Hematuria (moderate to severe) ( 30476138 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Hepatitis B ( 24162738 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) HIV-1 control ( 20041166 21051598 ) HIV-1 susceptibility ( 23935489 ) HIV-1 viral setpoint ( 26039976 ) Hypothyroidism ( 22493691 ) IgE levels ( 24324648 ) IgG galactosylation phenotypes (multivariate analysis) ( 28878392 ) Inflammatory bowel disease ( 28067908 ) Irritable bowel syndrome ( 33608531 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol ( 26582766 ) Leprosy ( 32421744 ) Leukoderma in response to rhododendrol ( 32558222 ) Lung cancer ( 28604730 ) Lymphocyte count ( 27863252 32888494 ) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693 ) Major depressive episode treated with electroconvulsive therapy ( 33483693 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Mean platelet volume ( 32888494 ) Monocyte count ( 29403010 ) Monocyte percentage of white cells ( 32888494 ) Myeloid white cell count ( 27863252 ) Myositis ( 26291516 ) Nasopharyngeal carcinoma ( 20512145 ) Neurociticism ( 29500382 ) Neuromyelitis optica ( 29769526 ) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526 ) Neutrophil count ( 27863252 29403010 32888494 ) Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis) ( 28062682 ) Non-albumin protein levels ( 29403010 ) Offspring birth weight ( 31043758 ) Perceived unattractiveness to mosquitoes ( 28199695 ) Plantar warts ( 28928442 ) Pneumonia ( 28928442 ) Protein quantitative trait loci ( 18464913 ) Psoriasis ( 18364390 18369459 19169254 20953188 20953190 23143594 30921485 ) Psoriasis vulgaris ( 26626624 ) Psoriatic arthritis ( 20953186 26626624 ) Red blood cell count ( 32888494 ) Response to hepatitis B vaccine ( 29534301 ) Reticulocyte count ( 27863252 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Self-reported allergy ( 23817569 ) Serum albumin levels ( 29403010 ) Setpoint viral load in HIV-1 infection ( 26553974 ) Severity of facial solar lentigines ( 27327535 ) Shingles ( 28928442 ) Small cell lung carcinoma ( 28604730 ) Squamous cell lung carcinoma ( 28604730 ) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 28714469 ) Takayasu arteritis ( 25604533 ) Tonsillectomy ( 27182965 28928442 ) Tonsillitis ( 30037793 ) Triglyceride levels ( 33339817 ) Tuberculosis ( 28928442 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Ulcerative colitis ( 28067908 ) Vitiligo ( 20526339 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) White blood cell count ( 21738480 27863252 28158719 29403010 32888494 ) White blood cell count (basophil) ( 29403010 ) White blood cell count (lymphocyte) ( 28158719 )
Interacting Genes		10 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1	25 interacting genes: ACKR5 B2M BATF2 CALR CD8A CDC25A GPR37 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 MAPK8IP2 NPSR1 OPRL1 PRRG4 TANK TAP2 TAPBP UBC YBX1
Entrez ID		6891	3107
HPRD ID		01360	00829
Ensembl ID		ENSG00000204267	ENSG00000204525
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5	O19617 P10321 Q6R739 Q95HC2
PDB IDs		5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J	1EFX 1IM9 1QQD 3BZF 4NT6 5VGD 5VGE 5W67 5W69 5W6A 6JTO 6PA1 6PAG
GO Terms Enriched among Interactors		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle	MHC Class Ib Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Immune Response-regulating Signaling Pathway MHC Class I Protein Binding Regulation Of Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Immune System Process Signal Transduction Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent MHC Class Ib Protein Complex Binding Plasma Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Fc Receptor Mediated Inhibitory Signaling Pathway Immune System Process Immune Response Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Binding Inhibitory MHC Class I Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Adaptive Immune Response Ubiquitin Protein Ligase Binding Protein Folding Chaperone Interleukin-10-mediated Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Protein Folding In Endoplasmic Reticulum Protein Folding Regulation Of Dendritic Cell Differentiation Amyloid-beta Binding T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Neuropeptide Receptor Activity Negative Regulation Of Monoatomic Ion Transport Protein-folding Chaperone Binding Neuropeptide Signaling Pathway Regulation Of T Cell Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immune System Process Unfolded Protein Binding