HLA-G and COPB1

Number of citations of the paper that reports this interaction (PMID 12582157)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HLA-G	COPB1
Gene Name		major histocompatibility complex, class I, G	coatomer protein complex, subunit beta 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane COPI Vesicle Coat Intracellular Membrane-bounded Organelle
	Molecular Function	Receptor Binding Peptide Antigen Binding Protein Homodimerization Activity	Structural Molecule Activity Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cellular Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Negative Regulation Of Dendritic Cell Differentiation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport Viral Process COPI Coating Of Golgi Vesicle Membrane Organization
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	COPI Mediated Transport Golgi to ER Retrograde Transport
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) IgE levels ( 22075330) Rheumatoid arthritis ( 21653640)
Protein-Protein Interactions		9 interactors: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2	32 interactors: ADAM19 APP ARCN1 ARF1 COPE COPG1 COPG2 ERBB2IP FOXB1 GRB2 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 LZTS2 NUB1 PDGFRB PRKCE RGS2 RGS4 RHOQ SERTAD1 SNTA1 TANK TAPBP TMED10 TRIM37 UBQLN4 VPS18 XRCC6
Entrez ID		3135	1315
HPRD ID		00834	02981
Ensembl ID		ENSG00000204632	ENSG00000129083
Uniprot IDs		P17693 Q29897 Q31611 Q5RJ85 Q6DU14	P53618
PDB IDs		1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Defense Response Cytosol To ER Transport Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Single Organismal Cell-cell Adhesion Viral Process Response To Stress Intracellular Transport Of Virus Immune Response Antigen Processing And Presentation Of Peptide Antigen Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Calcium Ion Transport T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cellular Defense Response Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Cytotoxic T Cell Differentiation Negative Regulation Of Interferon-beta Secretion Lymphocyte Activation Regulation Of Defense Response To Virus Regulation Of T Cell Mediated Cytotoxicity Peptide Transport Negative Regulation Of Ion Transport	Retrograde Vesicle-mediated Transport, Golgi To ER COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Vesicle Targeting Localization Within Membrane Intracellular Transport Golgi Vesicle Transport Membrane Budding Vesicle-mediated Transport Establishment Of Localization In Cell Innate Immune Response Cellular Localization Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Immune Response Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Immune System Process Regulation Of MAPK Cascade Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Phosphorylation Defense Response Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization ERBB Signaling Pathway Regulation Of Protein Metabolic Process Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Actin Cytoskeleton Organization Regulation Of Immune Response Protein Localization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Protein Transport Positive Regulation Of Immune Response Negative Regulation Of MAP Kinase Activity Transport Organelle Localization Regulation Of Phospholipase Activity Regulation Of Immune System Process Antigen Processing And Presentation Of Peptide Antigen Cellular Copper Ion Homeostasis Cellular Protein Localization Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation
Tagcloud ?			ca037 ca530 cadd chlamydiaceae chlamydophila copd1 copd2 inca incc pkn5 psittaci scc1 scc2 scc3 sctc sctd sctj sctl sctn sctq sctr scts sctt sctu sctv sctw t3s t3ss tarp
Tagcloud (Difference) ?			ca037 ca530 cadd chlamydiaceae chlamydophila copd1 copd2 inca incc pkn5 psittaci scc1 scc2 scc3 sctc sctd sctj sctl sctn sctq sctr scts sctt sctu sctv sctw t3s t3ss tarp
Tagcloud (Intersection) ?