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HLA-G and KIR2DL4
Number of citations of the paper that reports this interaction (PMID
10190900
)
85
Data Source:
HPRD
(in vitro, in vivo)
HLA-G
KIR2DL4
Gene Name
major histocompatibility complex, class I, G
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Plasma Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Molecular Function
Receptor Binding
Peptide Antigen Binding
Protein Homodimerization Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Biological Process
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Tolerance Induction
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Cellular Defense Response
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-12 Production
Negative Regulation Of T Cell Proliferation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Negative Regulation Of Dendritic Cell Differentiation
Cellular Defense Response
Signal Transduction
Regulation Of Immune Response
Pathways
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Drugs
Diseases
GWAS
Crohn's disease (
22412388
)
IgE levels (
22075330
)
Rheumatoid arthritis (
21653640
)
Protein-Protein Interactions
9 interactors:
B2M
CD8A
COPB1
KIR2DL4
KLRD1
LILRB1
LILRB2
TAP1
TAP2
5 interactors:
FCER1G
HLA-G
RBPMS
RNF216
TRIP6
Entrez ID
3135
3805
HPRD ID
00834
16082
Ensembl ID
ENSG00000204632
ENSG00000189013
Uniprot IDs
P17693
Q29897
Q31611
Q5RJ85
Q6DU14
Q99706
PDB IDs
1YDP
2D31
2DYP
3BZE
3CDG
3CII
3KYN
3KYO
Enriched GO Terms of Interacting Partners
?
Regulation Of Immune System Process
Defense Response
Cytosol To ER Transport
Regulation Of Immune Response
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Fc Receptor Mediated Inhibitory Signaling Pathway
Intracellular Transport Of Viral Protein In Host Cell
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-inhibiting Signal Transduction
Antigen Processing And Presentation
Regulation Of Dendritic Cell Differentiation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Single Organismal Cell-cell Adhesion
Viral Process
Response To Stress
Intracellular Transport Of Virus
Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Response To Other Organism
Response To Biotic Stimulus
Negative Regulation Of Calcium Ion Transport
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Cellular Defense Response
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Positive Regulation Of Immune System Process
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Cytotoxic T Cell Differentiation
Negative Regulation Of Interferon-beta Secretion
Lymphocyte Activation
Regulation Of Defense Response To Virus
Regulation Of T Cell Mediated Cytotoxicity
Peptide Transport
Negative Regulation Of Ion Transport
Positive Regulation Of Intracellular Transport
Regulation Of Intracellular Transport
Regulation Of Cytokine Production
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Nucleocytoplasmic Transport
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Type III Hypersensitivity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Positive Regulation Of Transport
Positive Regulation Of Adaptive Immune Response
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Type I Hypersensitivity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Positive Regulation Of Intracellular Protein Transport
Regulation Of Protein Import Into Nucleus
Serotonin Secretion By Platelet
Positive Regulation Of Type IIa Hypersensitivity
Regulation Of Adaptive Immune Response
Regulation Of Protein Localization To Nucleus
Regulation Of Cellular Localization
Regulation Of Nucleocytoplasmic Transport
Antigen Processing And Presentation Of Peptide Antigen
Serotonin Secretion
Release Of Cytoplasmic Sequestered NF-kappaB
Positive Regulation Of Regulatory T Cell Differentiation
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Protein Transport
Negative Regulation Of Mast Cell Apoptotic Process
Negative Regulation Of Dendritic Cell Differentiation
Immune Response-inhibiting Signal Transduction
Antigen Processing And Presentation
Regulation Of Immune System Process
Regulation Of Mast Cell Apoptotic Process
Serotonin Transport
Positive Regulation Of Hypersensitivity
Positive Regulation Of Cell Activation
Regulation Of Dendritic Cell Differentiation
Neutrophil Activation Involved In Immune Response
Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Protein Transport
Positive Regulation Of Cytokine Production
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Immune System Process
Positive Regulation Of T Cell Tolerance Induction
Positive Regulation Of Mast Cell Degranulation
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Phagocytosis, Engulfment
Positive Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Mast Cell Activation
Regulation Of SMAD Protein Import Into Nucleus
Tagcloud
?
accessible
cd28
cd4
competency
conferred
demethylated
demethylation
di
dimethylated
dimethylation
dnmt
hut78
ig
inactive
indicative
jurkat
killer
kirs
lys
methyltransferase
modifications
mostly
nk
partially
strikingly
susceptible
transcribe
trimethylated
Tagcloud (Difference)
?
accessible
cd28
cd4
competency
conferred
demethylated
demethylation
di
dimethylated
dimethylation
dnmt
hut78
ig
inactive
indicative
jurkat
killer
kirs
lys
methyltransferase
modifications
mostly
nk
partially
strikingly
susceptible
transcribe
trimethylated
Tagcloud (Intersection)
?