VAMP1 and VAPB

Number of citations of the paper that reports this interaction (PMID 9920726)
31

Data Source:
HPRD (in vitro)

		VAMP1	VAPB
Gene Name		vesicle-associated membrane protein 1 (synaptobrevin 1)	VAMP (vesicle-associated membrane protein)-associated protein B and C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Cell Junction Synaptic Vesicle Membrane SNARE Complex Azurophil Granule Membrane Specific Granule Membrane Neuron Projection Tertiary Granule Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein Heterodimerization Activity Beta-tubulin Binding
	Biological Process	Exocytosis Vesicle Fusion Pathogenesis SNARE Complex Assembly	Sphingolipid Metabolic Process Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Small Molecule Metabolic Process Negative Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell COPII-coated Vesicle Budding
Pathways		Toxicity of botulinum toxin type G (BoNT/G) Uptake and actions of bacterial toxins Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type F (BoNT/F) Neurotoxicity of clostridium toxins	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Hip geometry ( 17903296)
Protein-Protein Interactions		9 interactors: BCAP31 CCDC155 SNAP23 SNAP29 STX1A STX1B STX4 VAPA VAPB	15 interactors: FAF1 GPR25 MTNR1A OSBPL2 RMDN2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VAPA VHL VKORC1
Entrez ID		6843	9217
HPRD ID		01716	09300
Ensembl ID		ENSG00000139190	ENSG00000124164
Uniprot IDs		P23763	O95292 Q53XM7
PDB IDs			3IKK
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Organization Membrane Fusion Vesicle Fusion Synaptic Vesicle Exocytosis Organelle Fusion Neurotransmitter Secretion Synaptic Vesicle Transport Establishment Of Localization In Cell Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Cellular Localization Vesicle-mediated Transport Neurotransmitter Transport Organelle Localization Membrane Organization Establishment Of Vesicle Localization Vesicle Localization Golgi Vesicle Transport Exocytosis Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Intracellular Transport Secretion By Cell Protein Localization Organelle Organization Synaptic Transmission Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Positive Regulation Of Viral Release From Host Cell Protein Transport Vesicle Docking Establishment Of Protein Localization Membrane Docking Synaptic Vesicle Priming ER To Golgi Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission Cell-cell Signaling Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Transport Positive Regulation Of Viral Genome Replication COPII-coated Vesicle Budding Regulation Of Viral Release From Host Cell Cellular Protein Localization Interaction With Symbiont Regulation Of Synaptic Vesicle Exocytosis	Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Vesicle Docking Membrane Docking Membrane Organization Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Neurotransmitter Levels Calcium Ion-dependent Exocytosis Neurotransmitter Transport Cellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Secretion By Cell Golgi Vesicle Transport SNARE Complex Assembly Cellular Localization Secretion Establishment Of Organelle Localization Positive Regulation Of Synaptic Transmission Protein Localization Establishment Of Localization In Cell Organelle Localization Response To Hydroperoxide Glutamate Secretion Regulation Of Exocytosis Intracellular Protein Transport Intracellular Transport Regulation Of Insulin Secretion Pathogenesis Regulation Of Peptide Hormone Secretion Synaptic Transmission Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Transport Acid Secretion Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Protein Transport Regulation Of Protein Localization Organelle Organization
Tagcloud ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp2	2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle
Tagcloud (Difference) ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp2	2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle
Tagcloud (Intersection) ?