GOSR2 and STX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		GOSR2	STX4
Description		golgi SNAP receptor complex member 2	syntaxin 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic	Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Aortic root size ( 28394258) Aortic valve area ( 33125279) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Congenital heart disease (anomalies of thoracic arteries and veins) ( 33201861) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Pulse pressure ( 28739976 27841878 30578418) QRS duration ( 27577874 21076409 30012220) QT interval ( 29874175) Systolic blood pressure ( 30578418 27618447 28739976 27618452 28135244 21909115 27841878)	Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)
Interacting Genes		53 interacting genes: APP AQP6 ARF1 ARL13B BIK BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 ERGIC3 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SLC35H1 SLC61A1 SLC71A2 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1	65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1
Entrez ID		9570	6810
HPRD ID		04937	01722
Ensembl ID		ENSG00000108433	ENSG00000103496
Uniprot IDs		A0A1W2PPP5 A0A1W2PQ77 A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRC2 A0A1W2PRL0 I3NI02 O14653	B7Z425 Q12846
PDB IDs		3EG9
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ascorbate Homeostasis Positive Regulation Of Protein Localization To Cell Surface Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Vesicle Docking Bile Acid:sodium Symporter Activity Organelle Localization By Membrane Tethering Membrane Fusion Regulation Of Toll Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Membrane Docking SNAP Receptor Activity Protein Binding Fatty Acid Elongation, Saturated Fatty Acid Vesicle Fusion Regulation Of Protein Localization To Cell Surface Organelle Membrane Fusion Meiotic Nuclear Membrane Microtubule Tethering Complex SNARE Complex Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acetylcholine Receptor Binding Very Long-chain Fatty Acid Biosynthetic Process Organelle Fusion Fatty Acid Elongation Endoplasmic Reticulum Organization	SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport
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