GOSR2 and STX4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GOSR2	STX4
Gene Name		golgi SNAP receptor complex member 2	syntaxin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane SNARE Complex Late Endosome Membrane	Extracellular Space Intracellular Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	SNARE Binding Transporter Activity SNAP Receptor Activity	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Protein Targeting To Vacuole ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process Vesicle Fusion With Golgi Apparatus Membrane Fusion	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Exocytosis Platelet Activation Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Positive Regulation Of Immunoglobulin Secretion Long-term Synaptic Potentiation Membrane Organization Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Response to elevated platelet cytosolic Ca2+ Translocation of GLUT4 to the plasma membrane Disinhibition of SNARE formation Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Systolic blood pressure ( 21909115) Ventricular conduction ( 21076409)
Protein-Protein Interactions		10 interactors: APP ARF1 CCDC155 GOLGA8EP GOLGA8F NAPA STX4 STX5 STX6 USO1	48 interactors: ACTB BET1 CYBRD1 DLG1 GIMAP5 GOSR2 ITSN2 LLGL1 NAPA NAPB NSF PSMA3 RAB11A RAB4A RAB5A SCRIB SEC22A SEPT5 SNAP23 SNAP25 SNAP29 SNAP47 STX12 STX16 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TXLNA TXLNB TXLNG VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B
Entrez ID		9570	6810
HPRD ID		04937	01722
Ensembl ID		ENSG00000108433	ENSG00000103496
Uniprot IDs		I3L4Z6 O14653	A8MXY0 B7Z425 Q12846
PDB IDs		3EG9
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Membrane Fusion Vesicle Fusion Vesicle Organization Establishment Of Localization In Cell Organelle Fusion Cellular Localization Vesicle-mediated Transport Intracellular Transport Membrane Organization Protein Transport Establishment Of Protein Localization Vesicle Docking Post-Golgi Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus Membrane Docking Intracellular Protein Transport Protein Localization Cellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Protein Localization Regulation Of Synaptic Transmission Transport Organelle Organization Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Organelle Localization Golgi Organization Chromosome Localization To Nuclear Envelope Involved In Synapsis ER To Golgi Vesicle-mediated Transport Synaptic Growth At Neuromuscular Junction Positive Regulation Of Eosinophil Degranulation Golgi Vesicle Docking SNARE Complex Disassembly Collateral Sprouting In Absence Of Injury Golgi Disassembly Transition Metal Ion Homeostasis Regulation Of Exocytosis Regulation Of Synaptic Plasticity Collateral Sprouting Axon Midline Choice Point Recognition Platelet Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Vesicle Priming Establishment Of Vesicle Localization Endosomal Transport Vesicle Localization Axon Choice Point Recognition Golgi Ribbon Formation	Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization Vesicle Organization Establishment Of Localization In Cell Cellular Localization Exocytosis Secretion By Cell Secretion Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Protein Localization Intracellular Transport Neurotransmitter Secretion Regulation Of Exocytosis Regulation Of Cellular Localization Vesicle Docking Regulation Of Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Membrane Docking Regulation Of Neurotransmitter Levels Intracellular Protein Transport Neurotransmitter Transport Synaptic Vesicle Exocytosis Vesicle Fusion With Golgi Apparatus Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Secretion Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Organelle Organization Endomembrane System Organization Cytoplasmic Transport SNARE Complex Assembly Endosomal Transport Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Membrane Organelle Localization Establishment Of Organelle Localization Synaptic Transmission Golgi To Plasma Membrane Transport Regulation Of Protein Localization ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Exocytosis
Tagcloud ?		430g bounding came cavus clonic clue creatine deformities discharges electroencephalography epilepsies founder g144w myoclonic myoclonus norway pes photosensitivity predominance ready relentless scoliosis seizures snap spike syndactyly tonic uniformly wheelchair	address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a
Tagcloud (Difference) ?		430g bounding came cavus clonic clue creatine deformities discharges electroencephalography epilepsies founder g144w myoclonic myoclonus norway pes photosensitivity predominance ready relentless scoliosis seizures snap spike syndactyly tonic uniformly wheelchair	address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a
Tagcloud (Intersection) ?