CDKL5 and SPTBN4

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		CDKL5	SPTBN4
Name		cyclin dependent kinase like 5	spectrin beta, non-erythrocytic 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Dendritic Growth Cone Ciliary Tip Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Adherens Junction Cell Cortex Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Axon Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Juxtaparanode Region Of Axon Extracellular Exosome Cell Body Fiber
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Protein Serine Kinase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Neuron Migration Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Axon Extension Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Cell Cycle Regulation Of Postsynapse Organization Regulation Of Cilium Assembly	Regulation Of Sodium Ion Transport Axonogenesis Neuromuscular Junction Development Sensory Perception Of Sound Adult Walking Behavior Intracellular Protein Localization Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Adult Behavior Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Neuromuscular Process Actin Filament Capping Cardiac Conduction Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		None	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Early infantile epileptic encephalopathy; Ohtahara syndrome	None
GWAS		Estimated glomerular filtration rate ( 31015462 )	Antibody level in response to infection ( 25758998 ) Carotid intima media thickness (mean) ( 31801372 ) Hemoglobin levels ( 32327693 ) Pulse pressure ( 30578418 )
Interacting Genes		4 interacting genes: MLH1 SKIC2 SPTBN4 TACC3	18 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CFAP298 CLK1 DISC1 GADD45A GSK3B MORC3 NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		6792	57731
HPRD ID		02190	09372
Ensembl ID		ENSG00000008086	ENSG00000160460
Uniprot IDs		O76039	Q9H254
PDB IDs		4BGQ 8CIE	Not available
GO Terms Enriched among Interactors		Organelle Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment RNA Catabolic Process Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule Mismatch Repair Complex MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Cytoskeletal Protein-membrane Anchor Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination 3'-5' RNA Helicase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Hillock Cell Body Fiber Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Metaphase/anaphase Transition Of Cell Cycle Telomere Localization Paranode Region Of Axon Spectrin Nucleobase-containing Compound Catabolic Process Spindle Midzone Assembly ATP Hydrolysis Activity Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Negative Regulation Of Heart Rate Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates Organelle Localization ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Node Of Ranvier	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Axon Extension Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Kinase Activity Spectrin Binding Cytoskeleton Kinase Activity Regulation Of Axonogenesis Centrosome Ciliary Basal Body Regulation Of Postsynapse Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Cell Projection Organization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Neuron Projection Organization Peptidyl-serine Phosphorylation Regulation Of Long-term Synaptic Potentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Neuron Projection Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Axon Extension Virus-like Capsid Insulin Secretion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Projection Maintenance Of Protein Location Maintenance Of Protein Location In Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Anatomical Structure Morphogenesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Modulation Of Chemical Synaptic Transmission Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Transport Vesicle Membrane HSP90-CDC37 Chaperone Complex Negative Regulation Of Embryonic Development Organelle Organization Positive Regulation Of Cell Communication By Electrical Coupling Cell Projection Morphogenesis Cytoskeleton Organization Regulation Of Biological Quality Neuron Projection Morphogenesis Synapse