CDKL5 and TACC3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		CDKL5	TACC3
Description		cyclin dependent kinase like 5	transforming acidic coiled-coil containing protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Dendritic Growth Cone Ciliary Tip Glutamatergic Synapse	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Neuron Migration Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Axon Extension Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Cell Cycle Regulation Of Postsynapse Organization Regulation Of Cilium Assembly	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Migration Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways			NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Estimated glomerular filtration rate ( 31015462)	Appendicular lean mass ( 33097823) Bladder cancer ( 20972438 24163127) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		4 interacting genes: MLH1 SKIC2 SPTBN4 TACC3	30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 CATSPERT CCHCR1 CDC20B CDKL5 CIB3 CLIP4 DRC10 EIF3C GDF15 KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		6792	10460
HPRD ID		02190	05601
Ensembl ID		ENSG00000008086	ENSG00000013810
Uniprot IDs		O76039	A0A087WUE2 Q9Y6A5
PDB IDs		4BGQ 8CIE	5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?		Organelle Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment RNA Catabolic Process Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule Mismatch Repair Complex MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Cytoskeletal Protein-membrane Anchor Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination 3'-5' RNA Helicase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Hillock Cell Body Fiber Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Metaphase/anaphase Transition Of Cell Cycle Telomere Localization Paranode Region Of Axon Spectrin Nucleobase-containing Compound Catabolic Process Spindle Midzone Assembly ATP Hydrolysis Activity Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Negative Regulation Of Heart Rate Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates Organelle Localization ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Node Of Ranvier	Cytoplasm Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Microtubule-based Process Mitotic Centrosome Separation Centrosome Localization Axon Hillock Centrosome Separation
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