STK3 and RASSF1

Number of citations of the paper that reports this interaction (PMID 14729613)
15

Data Source:
BioGRID (two hybrid)

		STK3	RASSF1
Gene Name		serine/threonine kinase 3	Ras association (RalGDS/AF-6) domain family member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity	Protein Binding Zinc Ion Binding Identical Protein Binding Protein N-terminus Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Negative Regulation Of Cell Cycle Arrest
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A	33 interactors: ATP2B4 AURKA AURKB C7orf25 C8orf33 CDC20 CNKSR1 DAXX DDB1 E4F1 EXOSC8 HRAS IGFBP5 KCNE3 KDM1A MAP1B MAP1S MAPK8 MDM2 MOAP1 MST1 NUDT10 RASSF5 SAV1 STK3 STK4 SUV39H1 SUV39H2 TNFRSF10A TNFRSF1A TUBB TUBG1 XPA
Entrez ID		6788	11186
HPRD ID		05433	05470
Ensembl ID		ENSG00000104375	ENSG00000068028
Uniprot IDs		B3KYA7 Q13188	Q9NS23
PDB IDs		4HKD 4L0N 4LG4 4LGD	2KZU
Enriched GO Terms of Interacting Partners?		Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death	Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Protein Binding Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Death Hippo Signaling Response To Abiotic Stimulus Mitotic Cell Cycle Process Positive Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Organ Growth Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Primitive Hemopoiesis Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Transferase Activity Cell Cycle Response To UV Negative Regulation Of Protein Binding Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Organelle Organization Endocardium Development Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Hepatocyte Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Process Response To Light Stimulus Negative Regulation Of Developmental Growth Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1	bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley
Tagcloud (Difference) ?		contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1	bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley
Tagcloud (Intersection) ?