RMI1 and NR1H2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RMI1	NR1H2
Description		RecQ mediated genome instability 1	nuclear receptor subfamily 1 group H member 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body RecQ Family Helicase-topoisomerase III Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Apolipoprotein A-I Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding ATPase Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess DNA Replication Response To Glucose Multicellular Organism Growth Glucose Homeostasis Resolution Of DNA Recombination Intermediates	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis MRNA Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs			GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Childhood body mass index ( 33045005) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 25231870 27182965) Molar-incisor hypomineralization ( 23918034) Response to statin therapy ( 20339536) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Triglycerides ( 30275531)
Interacting Genes		5 interacting genes: FANCM HSPA13 NR1H2 PFDN1 UBE3A	52 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A TTC3 UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		80010	7376
HPRD ID		09867	02660
Ensembl ID		ENSG00000178966	ENSG00000131408
Uniprot IDs		Q9H9A7	F1D8P7 P55055
PDB IDs		3MXN 3NBH 3NBI 4CGY 4CHT 4DAY 7XUV	1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Protein Folding Chaperone Positive Regulation Of Post-translational Protein Modification Sperm Entry Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Hormone-mediated Signaling Pathway Regulation Of Golgi Lumen Acidification Regulation Of High-density Lipoprotein Particle Assembly Protein Folding Prefoldin Complex Positive Regulation Of Protein Localization To Lysosome Regulation Of Protein Ubiquitination Positive Regulation Of Cellular PH Reduction Regulation Of Post-translational Protein Modification Intracellular Receptor Signaling Pathway Apolipoprotein A-I Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Double-strand Break Repair Via Synthesis-dependent Strand Annealing Four-way Junction Helicase Activity FANCM-MHF Complex Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Prostate Gland Growth Negative Regulation Of Cholesterol Storage Progesterone Receptor Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation 3'-5' DNA Helicase Activity Fanconi Anaemia Nuclear Complex Negative Regulation Of Amyloid Fibril Formation Phosphatidylcholine Acyl-chain Remodeling ATP Hydrolysis Activity Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Nuclear Retinoid X Receptor Binding Resolution Of Meiotic Recombination Intermediates Four-way Junction DNA Binding Regulation Of Amyloid Fibril Formation Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Protein Localization Androgen Receptor Signaling Pathway	Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor Binding Chromatin Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Nutrient Levels Response To Lipid Nuclear Retinoic Acid Receptor Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process
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