SSR1 and ODC1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SSR1	ODC1
Name		signal sequence receptor subunit 1	ornithine decarboxylase 1
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Protein Homodimerization Activity
	Biological Process	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Population Proliferation	Kidney Development Polyamine Metabolic Process Polyamine Biosynthetic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Putrescine Biosynthetic Process From Arginine, Via Ornithine Regulation Of Protein Catabolic Process
Pathways		SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines
Drugs		None	Pyridoxal phosphate Spermine Sildenafil Valproic acid Putrescine Pyridoxine phosphate N-Pyridoxyl-Glycine-5-Monophosphate L-Eflornithine N(6)-(pyridoxal phosphate)-L-lysine Geneticin Eflornithine
GWAS		Brain morphology (MOSTest) ( 32665545 ) Ewing sarcoma ( 30093639 ) Hip circumference adjusted for BMI ( 34021172 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 24509480 28869590 30718926 32499647 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: NPC2	None recorded
Interacting Genes		8 interacting genes: DKC1 EEF1A1 HSPA13 NUP54 ODC1 PTN SERPINF2 UTP14A	17 interacting genes: BAAT CSNK2B GORASP2 HEMGN KAT5 MAP2K1 NANS OAZ1 OAZ2 RSC1A1 SSR1 STX17 TDRD7 TK1 TMOD1 TSTD2 ZNF510
Entrez ID		6745	4953
HPRD ID		02924	01324
Ensembl ID		ENSG00000124783	ENSG00000115758
Uniprot IDs		C9JBX5 P43307	B4DXF8 P11926
PDB IDs		8B6L	1D7K 2ON3 2OO0 4ZGY 5BWA 7S3F 7S3G 7U6P 7U6U 9B8M 9B8N
GO Terms Enriched among Interactors		None	Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Viral Translational Frameshifting Polyamine Biosynthetic Process Polyamine Metabolic Process Negative Regulation Of Transmembrane Transport Golgi Organization Viral Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process