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STAT5B and KIT
Number of citations of the paper that reports this interaction (PubMedID
17554063
)
52
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vivo)
STAT5B
KIT
Description
signal transducer and activator of transcription 5B
KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Cytoplasm
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Mitotic Cell Cycle
Luteinization
Natural Killer Cell Differentiation
Natural Killer Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Sex Differentiation
Female Pregnancy
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Lymphocyte Differentiation
Regulation Of Cell Adhesion
B Cell Differentiation
Erythrocyte Differentiation
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
Myeloid Cell Apoptotic Process
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Erythropoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Natural Killer Cell Mediated Cytotoxicity
Progesterone Metabolic Process
Gamma-delta T Cell Differentiation
T Cell Homeostasis
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Activated T Cell Proliferation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
Regulation Of Hemopoiesis
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Chemotaxis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Spermatid Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Gonad Development
Visual Learning
Male Gonad Development
Response To Radiation
Positive Regulation Of Gene Expression
Programmed Cell Death
Cell Migration
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Actin Cytoskeleton Organization
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Positive Regulation Of Mast Cell Cytokine Production
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Pigmentation
Tongue Development
Leukocyte Activation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Developmental Pigmentation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Regulation Of Developmental Process
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Negative Regulation Of Reproductive Process
Pathways
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
Transcriptional and post-translational regulation of MITF-M expression and activity
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Dasatinib
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
Linifanib
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Diseases
Growth hormone insensitivity with immunodeficiency
Acute myeloid leukemia (AML)
Piebaldism
GWAS
A body shape index (
34021172
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
34103634
31361310
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
23128233
27569725
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
28017375
29403010
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
28017375
29403010
28453575
)
Mean corpuscular volume (
28453575
28017375
20139978
29403010
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
31928498
32203549
)
Interacting Genes
63 interacting genes:
AFTPH
APP
CBL
CBR1
CD247
CDKN1A
CHAF1A
CPAP
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
WEE2-AS1
92 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
Entrez ID
6777
3815
HPRD ID
05037
01287
Ensembl ID
ENSG00000173757
ENSG00000157404
Uniprot IDs
P51692
A0A0U2N547
A0A8I5KQZ6
A0A8I5KS03
A0A8I5QKL5
A0A8I5QKP7
A0A8J8Z860
P10721
PDB IDs
6MBW
6MBZ
1PKG
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
7KHG
7KHJ
7KHK
7ZW8
7ZY6
8DFM
8DFP
8DFQ
8PQ9
8PQA
8PQB
8PQC
8PQD
8PQE
8PQF
8PQG
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Phosphorus Metabolic Process
Regulation Of MAPK Cascade
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Signal Transduction
Positive Regulation Of Receptor Signaling Pathway Via STAT
Positive Regulation Of MAPK Cascade
Phosphotyrosine Residue Binding
Response To Growth Factor
Animal Organ Development
Regulation Of Intracellular Signal Transduction
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Migration
Cell Surface Receptor Signaling Pathway Via STAT
Peptidyl-tyrosine Phosphorylation
Regulation Of Locomotion
Regulation Of Immune System Process
Regulation Of Signal Transduction
Regulation Of Cell Migration
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Motility
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Locomotion
Regulation Of Multicellular Organismal Process
Protein Tyrosine Kinase Activity
Regulation Of Cell Adhesion
Regulation Of Cell Motility
Regulation Of Cell Differentiation
Phosphorylation
Regulation Of Immune Response
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Cell Activation
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune System Process
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cell Activation
Cell Activation
Leukocyte Activation
Regulation Of Signal Transduction
Immune System Process
Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Cytosol
Lymphocyte Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Activation Of Immune Response
Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Activation
Positive Regulation Of T Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Immune Effector Process
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Plasma Membrane
Receptor Tyrosine Kinase Binding
Negative Regulation Of Immune System Process
T Cell Activation
Protein Phosphorylation
Fc Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphorylation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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