STAT5B and CENPJ

Number of citations of the paper that reports this interaction (PMID 12198240)
6

Data Source:
HPRD (two hybrid, in vivo)

		STAT5B	CENPJ
Gene Name		signal transducer and activator of transcription 5B	centromere protein J
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Centrosome Centriole Cytosol Microtubule Gamma-tubulin Small Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Glucocorticoid Receptor Binding Protein Dimerization Activity	Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Allantoin Metabolic Process Luteinization Response To Hypoxia Natural Killer Cell Differentiation Liver Development Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Acute-phase Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Microtubule Nucleation Centriole Replication Regulation Of Centriole Replication Microtubule Polymerization Cell Division
Pathways		Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs		Dasatinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		49 interactors: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG	13 interactors: ATN1 CIC CREBBP EPB41 GFI1B LAG3 LYST RELA STAT5A STAT5B TUBG1 YWHAG YWHAZ
Entrez ID		6777	55835
HPRD ID		05037	09876
Ensembl ID		ENSG00000173757	ENSG00000151849
Uniprot IDs		P51692	A8K8P1 Q9HC77
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Hormone Regulation Of MAPK Cascade Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Response To Cytokine Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Phosphorylation Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Cellular Response To Growth Hormone Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Signaling Regulation Of Phosphorus Metabolic Process Signal Transduction JAK-STAT Cascade Positive Regulation Of MAPK Cascade Defense Response Cell Communication Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Immune System Process Cellular Response To Cytokine Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Response To Peptide Hormone Positive Regulation Of Transferase Activity Innate Immune Response	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Cytokine Biosynthetic Process Development Of Secondary Male Sexual Characteristics Creatinine Metabolic Process Positive Regulation Of Innate Immune Response Isoleucine Metabolic Process Allantoin Metabolic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Peptide Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of B Cell Differentiation 2-oxoglutarate Metabolic Process Peyer's Patch Development Positive Regulation Of Cytokine Production Oxaloacetate Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Lymphocyte Activation Natural Killer Cell Differentiation Immune System Process Positive Regulation Of Activated T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Immune System Process
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast	acentriolar assembled biogenesis bipolar centriole centrioles centrosomes cilia cpap dividing embryos hedgehog interphase microtubule microtubules midgestation mutants organize organizing poles prolonging prometaphase rescued sas4 segregation spindle spindles survive undescribed
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast	acentriolar assembled biogenesis bipolar centriole centrioles centrosomes cilia cpap dividing embryos hedgehog interphase microtubule microtubules midgestation mutants organize organizing poles prolonging prometaphase rescued sas4 segregation spindle spindles survive undescribed
Tagcloud (Intersection) ?