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STAT5B and CDKN1A
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
STAT5B
CDKN1A
Description
signal transducer and activator of transcription 5B
cyclin dependent kinase inhibitor 1A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
Protein-containing Complex
PCNA-p21 Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine/threonine Kinase Binding
Protein Sequestering Activity
Molecular Function Activator Activity
Molecular Function Inhibitor Activity
Biological Process
Mitotic Cell Cycle
Luteinization
Natural Killer Cell Differentiation
Natural Killer Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Sex Differentiation
Female Pregnancy
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Lymphocyte Differentiation
Regulation Of Cell Adhesion
B Cell Differentiation
Erythrocyte Differentiation
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
Myeloid Cell Apoptotic Process
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Erythropoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Natural Killer Cell Mediated Cytotoxicity
Progesterone Metabolic Process
Gamma-delta T Cell Differentiation
T Cell Homeostasis
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Activated T Cell Proliferation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
Regulation Of Hemopoiesis
G1/S Transition Of Mitotic Cell Cycle
In Utero Embryonic Development
Protein Import Into Nucleus
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Epidermis Development
Response To UV
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of B Cell Proliferation
Mitotic G1 DNA Damage Checkpoint Signaling
Cellular Response To Amino Acid Starvation
Wound Healing
Tissue Regeneration
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Programmed Cell Death
Keratinocyte Proliferation
Positive Regulation Of DNA Replication
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Growth
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Import Into Nucleus
Regulation Of Cell Cycle
Cellular Response To Cell-matrix Adhesion
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Signal Transduction By P53 Class Mediator
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Neddylation
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Dasatinib
Valproic acid
Arsenic trioxide
Diseases
Growth hormone insensitivity with immunodeficiency
Cervical cancer
GWAS
A body shape index (
34021172
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
34103634
31361310
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
23128233
27569725
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Abdominal aortic aneurysm (
32981348
)
Alanine aminotransferase levels (
34315874
33547301
)
Aspartate aminotransferase levels (
34315874
33547301
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
30529582
31826910
22634755
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495597
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
JT interval (
29874175
)
Left ventricle wall thickness (
33495596
)
Left ventricular fractional shortening (
28394258
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
31251759
31217584
30679814
27659466
27577874
25035420
21076409
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Interacting Genes
63 interacting genes:
AFTPH
APP
CBL
CBR1
CD247
CDKN1A
CHAF1A
CPAP
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
WEE2-AS1
207 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
NSUN2
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
POLD2
PPM1D
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RANBP9
RB1
RBBP4
RBM48
REL
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SCML2
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TNKS
TRAF1
TRIM21
TRIM3
TRIM54
TRIM71
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
Entrez ID
6777
1026
HPRD ID
05037
00298
Ensembl ID
ENSG00000173757
ENSG00000124762
Uniprot IDs
P51692
P38936
PDB IDs
6MBW
6MBZ
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
7KQ0
7KQ1
8GJF
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Phosphorus Metabolic Process
Regulation Of MAPK Cascade
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Signal Transduction
Positive Regulation Of Receptor Signaling Pathway Via STAT
Positive Regulation Of MAPK Cascade
Phosphotyrosine Residue Binding
Response To Growth Factor
Animal Organ Development
Regulation Of Intracellular Signal Transduction
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Migration
Cell Surface Receptor Signaling Pathway Via STAT
Peptidyl-tyrosine Phosphorylation
Regulation Of Locomotion
Regulation Of Immune System Process
Regulation Of Signal Transduction
Regulation Of Cell Migration
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Motility
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Locomotion
Regulation Of Multicellular Organismal Process
Protein Tyrosine Kinase Activity
Regulation Of Cell Adhesion
Regulation Of Cell Motility
Regulation Of Cell Differentiation
Phosphorylation
Regulation Of Immune Response
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Cell Activation
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Nucleus
Nucleoplasm
Regulation Of Primary Metabolic Process
Cytoplasm
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cyclin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cytosol
Regulation Of Programmed Cell Death
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Signal Transduction
Cellular Response To Stress
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Binding
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Fibroblast Proliferation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
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Tagcloud (Intersection)
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