STAT5B and IL15

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		STAT5B	IL15
Description		signal transducer and activator of transcription 5B	interleukin 15
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity	Cytokine Activity Cytokine Receptor Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Luteinization Natural Killer Cell Differentiation Natural Killer Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Sex Differentiation Female Pregnancy Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Lymphocyte Differentiation Regulation Of Cell Adhesion B Cell Differentiation Erythrocyte Differentiation Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Interleukin-2 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Population Proliferation Natural Killer Cell Mediated Cytotoxicity Progesterone Metabolic Process Gamma-delta T Cell Differentiation T Cell Homeostasis Response To Peptide Hormone Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration Regulation Of Hemopoiesis	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Positive Regulation Of Cytokine Production NK T Cell Proliferation Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Negative Regulation Of Cold-induced Thermogenesis
Pathways		Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Dasatinib	Cefazolin
Diseases		Growth hormone insensitivity with immunodeficiency
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 34103634 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233 27569725) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		63 interacting genes: AFTPH APP CBL CBR1 CD247 CDKN1A CHAF1A CPAP CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 HNRNPA2B1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT LGALS14 LMO4 MAPK1 MED25 NCOR2 NMI NR3C1 PDGFRA PDGFRB PIK3R3 POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA RBBP4 SERTAD1 SHC1 SRC STAC STAP2 STAT1 STAT3 STAT5A SUOX TEK TFG TSSK3 USP2 WEE2-AS1	9 interacting genes: APP IL15RA IL2RB IL2RG POLR1H S100A6 S100P STAT5B TRAF3
Entrez ID		6777	3600
HPRD ID		05037	02776
Ensembl ID		ENSG00000173757	ENSG00000164136
Uniprot IDs		P51692	P40933
PDB IDs		6MBW 6MBZ	2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Receptor Signaling Pathway Via JAK-STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Response To Growth Factor Animal Organ Development Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Phosphorylation Regulation Of Locomotion Regulation Of Immune System Process Regulation Of Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Protein Tyrosine Kinase Activity Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Differentiation Phosphorylation Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Activation Positive Regulation Of Phosphate Metabolic Process Regulation Of Signaling Regulation Of Cell Communication	Interleukin-15 Receptor Activity Interleukin-15-mediated Signaling Pathway Positive Regulation Of Endocytosis Interleukin-2 Binding Interleukin-2 Receptor Activity Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Phagocytosis Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Endocytosis Endosome Interleukin-2-mediated Signaling Pathway Regulation Of Phagocytosis Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell Activation Transition Metal Ion Binding Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of B Cell Differentiation Natural Killer Cell Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Vesicle-mediated Transport Immune System Process Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of B Cell Differentiation Immune Response Regulation Of Lymphocyte Differentiation Cell Surface Regulation Of Cell Activation Cell Activation T Cell Differentiation In Thymus Lymphocyte Differentiation Regulation Of Natural Killer Cell Activation Protein Homodimerization Activity Natural Killer Cell Activation Coreceptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Mononuclear Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transport Positive Regulation Of Lymphocyte Activation Regulation Of Immune System Process External Side Of Plasma Membrane
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