SRY and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 16166090)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SRY	NHERF2
Description		sex determining region Y	NHERF family PDZ scaffold protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Calmodulin Binding DNA-binding Transcription Factor Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Sex Differentiation Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Male Gonad Development	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Interacting Genes		10 interacting genes: AR EP300 HDAC3 KPNB1 NHERF2 SMAD3 ZNF10 ZNF208 ZNF274 ZNF354C	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		6736	9351
HPRD ID		08364	05946
Ensembl ID		ENSG00000184895	ENSG00000065054
Uniprot IDs		A7WPU8 Q05066	H3BQS0 Q15599
PDB IDs		1HRY 1HRZ 1J46 1J47 2GZK 6EDB 7YHO 7YHP 7YHQ 9BVD	2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Propionyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Binding Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Chromatin Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Membraneless Organelle Assembly Regulation Of Gene Expression Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Macromolecule Biosynthetic Process Histone H4 Acetyltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Nucleus Organelle Assembly Negative Regulation Of Metabolic Process Regulation Of Nucleocytoplasmic Transport Acetyltransferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Transport Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of Intracellular Protein Transport Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Protein Localization To Nucleus Histone Acetyltransferase Activity NF-kappaB Binding Regulation Of Metabolic Process Regulation Of Cellular Localization	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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