SRY and ZNF274

Number of citations of the paper that reports this interaction (PubMedID 19850934)
36

Data Source:
BioGRID (pull down)

		SRY	ZNF274
Description		sex determining region Y	zinc finger protein 274
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Calmodulin Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Sex Differentiation Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Male Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation	Generic Transcription Pathway
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Cholesterol, total ( 25961943) LDL cholesterol ( 25961943) Ovarian cancer ( 30557369)
Interacting Genes		10 interacting genes: AR EP300 HDAC3 KPNB1 NHERF2 SMAD3 ZNF10 ZNF208 ZNF274 ZNF354C	3 interacting genes: NGFR SRY TRIM28
Entrez ID		6736	10782
HPRD ID		08364	05682
Ensembl ID		ENSG00000184895	ENSG00000171606
Uniprot IDs		A7WPU8 Q05066	A0A0A0MR47 Q96GC6
PDB IDs		1HRY 1HRZ 1J46 1J47 2GZK 6EDB 7YHO 7YHP 7YHQ 9BVD
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Propionyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Binding Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Chromatin Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Membraneless Organelle Assembly Regulation Of Gene Expression Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Macromolecule Biosynthetic Process Histone H4 Acetyltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Nucleus Organelle Assembly Negative Regulation Of Metabolic Process Regulation Of Nucleocytoplasmic Transport Acetyltransferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Transport Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of Intracellular Protein Transport Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Protein Localization To Nucleus Histone Acetyltransferase Activity NF-kappaB Binding Regulation Of Metabolic Process Regulation Of Cellular Localization	Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Hair Follicle Development Positive Regulation Of DNA-templated Transcription Death Receptor Activity Calmodulin Binding Positive Regulation Of Protein Localization To Nucleus Ubiquitin Protein Ligase Binding Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Nerve Growth Factor Binding Neurotrophin Binding Regulation Of Protein Localization To Nucleus Dorsal Aorta Development Ubiquitin-like Protein Ligase Activity Krueppel-associated Box Domain Binding Embryonic Placenta Morphogenesis Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Odontogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Male Gonad Development Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Protein Localization Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Male Sex Determination Cell Differentiation Regulation Of Odontogenesis Suppression Of Viral Release By Host Positive Regulation Of Biosynthetic Process Regulation Of Hair Follicle Development Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway SUMO Transferase Activity Genomic Imprinting Detection Of Temperature Stimulus Positive Regulation Of Endothelial Cell Apoptotic Process Sex Determination Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Developmental Process Sex Differentiation Regulation Of Hair Cycle Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Hair Follicle Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Aorta Development Regulation Of RNA Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?