SRY and ZNF354C

Number of citations of the paper that reports this interaction (PubMedID 19850934)
36

Data Source:
BioGRID (pull down)

		SRY	ZNF354C
Description		sex determining region Y	zinc finger protein 354C
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Membrane Nuclear Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Calmodulin Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Sex Differentiation Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Male Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sprouting Angiogenesis
Pathways		Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation	Generic Transcription Pathway
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: AR EP300 HDAC3 KPNB1 NHERF2 SMAD3 ZNF10 ZNF208 ZNF274 ZNF354C	7 interacting genes: CCDC6 LHX3 LHX4 LINC00624 LMO1 SRY TRIM28
Entrez ID		6736	30832
HPRD ID		08364	15785
Ensembl ID		ENSG00000184895	ENSG00000177932
Uniprot IDs		A7WPU8 Q05066	Q86Y25
PDB IDs		1HRY 1HRZ 1J46 1J47 2GZK 6EDB 7YHO 7YHP 7YHQ 9BVD
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Propionyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Binding Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Chromatin Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Membraneless Organelle Assembly Regulation Of Gene Expression Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Macromolecule Biosynthetic Process Histone H4 Acetyltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Nucleus Organelle Assembly Negative Regulation Of Metabolic Process Regulation Of Nucleocytoplasmic Transport Acetyltransferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Transport Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of Intracellular Protein Transport Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Protein Localization To Nucleus Histone Acetyltransferase Activity NF-kappaB Binding Regulation Of Metabolic Process Regulation Of Cellular Localization	Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Differentiation In Spinal Cord Placenta Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Prolactin Secreting Cell Differentiation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin-like Protein Ligase Activity Positive Regulation Of Biosynthetic Process Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Embryonic Placenta Morphogenesis DNA-binding Transcription Factor Binding Thyroid-stimulating Hormone-secreting Cell Differentiation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Male Gonad Development Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Spinal Cord Association Neuron Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Transcription Coactivator Activity DNA Binding Male Sex Determination Regulation Of Nucleobase-containing Compound Metabolic Process Suppression Of Viral Release By Host DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuroendocrine Cell Differentiation Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SUMO Transferase Activity Genomic Imprinting Sex Determination
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