DCTN1 and PGAM1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		DCTN1	PGAM1
Name		dynactin subunit 1	phosphoglycerate mutase 1
Structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cilium Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Cell Leading Edge Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Extracellular Region Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity Protein Kinase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Melanosome Transport Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance	Gluconeogenesis Glycolytic Process Canonical Glycolysis
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants	Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		None	Copper Artenimol
Diseases		Perry syndrome Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)	None
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		52 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 CTIF DCTN3 DISC1 DST DTNBP1 DYNC1I1 DYNC1I2 EEF1A1 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 LCOR MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B	8 interacting genes: ARL4D CEBPA DCTN1 ERBB2 PCNA PKP4 UNC5CL XRCC6
Entrez ID		1639	5223
HPRD ID		07206	01392
Ensembl ID		ENSG00000204843	ENSG00000171314
Uniprot IDs		A0A7P0Z4C3 Q14203	B7Z9E5 P18669 Q6FHU2
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7	1YFK 1YJX 4GPI 4GPZ 5Y2I 5Y2U 5Y35 5Y64 5Y65 5ZRM 5ZS8 6ISN 7XB7 7XB8 7XB9 8IT4 8IT5 8IT6 8IT7 8IT8 8ITB 8ITC 8ITD
GO Terms Enriched among Interactors		Cytosol Centrosome Microtubule-based Process Transport Along Microtubule Cytoskeleton Cytoskeleton-dependent Intracellular Transport Dynactin Binding Microtubule-based Transport Cytoplasm Organelle Transport Along Microtubule Microtubule-based Movement Cytoskeleton Organization Organelle Organization Minus-end-directed Organelle Transport Along Microtubule Protein Kinase Binding Regulation Of Microtubule-based Process Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Microtubule Plus-end Binding Microtubule Organizing Center Execution Phase Of Apoptosis Microtubule Cell Cortex Dynactin Complex Organelle Assembly Hippocampus Development Positive Regulation Of Cilium Assembly Axon Ciliary Basal Body Response To Light Stimulus Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Cellular Component Organization Response To Radiation Pyroptotic Inflammatory Response Perinuclear Region Of Cytoplasm Vesicle Transport Along Microtubule Regulation Of Microtubule Cytoskeleton Organization Organelle Localization Microtubule Cytoskeleton Establishment Of Vesicle Localization Non-motile Cilium Assembly Protein Binding Central Region Of Growth Cone Vesicle Cytoskeletal Trafficking Brain Morphogenesis Dynein Complex Binding Retrograde Axonal Transport Vesicle Localization Protein Localization To Cilium Regulation Of Cytoskeleton Organization	Protein-containing Complex Binding Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Neuromuscular Junction Development Positive Regulation Of Catalytic Activity Receptor Tyrosine Kinase Binding Damaged DNA Binding PCNA Complex Replisome CHOP-C/EBP Complex Negative Regulation Of Hemopoiesis Regulation Of Hemopoiesis Regeneration Response To Vitamin B2 White Fat Cell Proliferation Liver Development Response To Glucocorticoid Response To Corticosteroid C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Cell Cortex Region Mitotic Spindle Positive Regulation Of Neuromuscular Junction Development Spindle Pole Cell Junction Organization Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Immature T Cell Proliferation In Thymus Regulation Of Rho Protein Signal Transduction ERBB2-ERBB4 Signaling Pathway DNA End Binding Cellular Hyperosmotic Salinity Response Telomere Maintenance DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Telomere Organization Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation