DCTN1 and ACTR1A

Number of citations of the paper that reports this interaction (PMID 7878030)
91

Data Source:
HPRD (in vitro)

		DCTN1	ACTR1A
Gene Name		dynactin 1	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge	Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Associated Complex Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Protein Binding Dynein Binding	ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B	6 interactors: ACTR10 DCTN1 DCTN4 NUMA1 SPTBN1 SPTBN2
Entrez ID		1639	10121
HPRD ID		07206	05507
Ensembl ID		ENSG00000204843	ENSG00000138107
Uniprot IDs		Q14203 Q6MZZ3	P61163
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Actin Filament Capping Organelle Localization Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Complex Disassembly Mitotic Cell Cycle Process Negative Regulation Of Protein Complex Assembly Mitotic Cell Cycle Microtubule-based Process Establishment Of Localization In Cell Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Localization Common-partner SMAD Protein Phosphorylation Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition SMAD Protein Import Into Nucleus Microtubule-based Movement Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Cell Cycle Regulation Of Actin Cytoskeleton Organization Nuclear Migration Axon Guidance Vesicle-mediated Transport Regulation Of Actin Filament-based Process Cerebellar Purkinje Cell Layer Morphogenesis Cell Division Membrane Assembly Golgi To Plasma Membrane Protein Transport Regulation Of Cytoskeleton Organization Membrane Biogenesis Establishment Of Nucleus Localization Axonogenesis
Tagcloud ?		als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp	backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp	backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?