DCTN1 and BICD1

Number of citations: 35 (PubMedID 17139249)
Data Source: HPRD (in vivo)

		DCTN1	BICD1
Name		dynactin subunit 1	BICD cargo adaptor 1
Structure			No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cilium Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Cell Leading Edge Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Cytoplasmic Microtubule Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Secretory Vesicle
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Protein Kinase Binding Small GTPase Binding Proteinase Activated Receptor Binding Dynactin Binding Dynein Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Melanosome Transport Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance	RNA Processing Intracellular MRNA Localization Anatomical Structure Morphogenesis Virion Assembly Protein Localization To Organelle Stress Granule Assembly Constitutive Secretory Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Centrosome
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants	COPI-independent Golgi-to-ER retrograde traffic
Diseases		Perry syndrome Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)	None
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Refractive error ( 32231278 )	Emphysema-related traits ( 20709820 ) Fourth ventricle volume ( 31530798 ) Intralaminar thalamic nuclei volume ( 34006833 ) Left ventricular mass x antihypertensive treatment interaction ( 31407531 ) Normalized brain volume ( 19010793 ) Obesity-related traits ( 23251661 ) Pancreatic cancer ( 20686608 ) Parkinson's disease ( 32201043 )
Interacting Genes		52 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 CTIF DCTN3 DISC1 DST DTNBP1 DYNC1I1 DYNC1I2 EEF1A1 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 LCOR MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B	15 interacting genes: ALPI CPNE4 DCTN1 DCTN2 DISC1 DSCAM DYNC1I1 FXR1 GSK3A GSK3B MAPK14 NIN PTPN23 RAB6A STAT3
Entrez ID		1639	636
HPRD ID		07206	03730
Ensembl ID		ENSG00000204843	ENSG00000151746
Uniprot IDs		A0A7P0Z4C3 Q14203	A8MVZ6 F8VZX7 Q96G01
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7	Not available
GO Terms Enriched among Interactors		Cytosol Centrosome Microtubule-based Process Transport Along Microtubule Cytoskeleton Cytoskeleton-dependent Intracellular Transport Dynactin Binding Microtubule-based Transport Cytoplasm Organelle Transport Along Microtubule Microtubule-based Movement Cytoskeleton Organization Organelle Organization Minus-end-directed Organelle Transport Along Microtubule Protein Kinase Binding Regulation Of Microtubule-based Process Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Microtubule Plus-end Binding Microtubule Organizing Center Execution Phase Of Apoptosis Microtubule Cell Cortex Dynactin Complex Organelle Assembly Hippocampus Development Positive Regulation Of Cilium Assembly Axon Ciliary Basal Body Response To Light Stimulus Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Cellular Component Organization Response To Radiation Pyroptotic Inflammatory Response Perinuclear Region Of Cytoplasm Vesicle Transport Along Microtubule Regulation Of Microtubule Cytoskeleton Organization Organelle Localization Microtubule Cytoskeleton Establishment Of Vesicle Localization Non-motile Cilium Assembly Protein Binding Central Region Of Growth Cone Vesicle Cytoskeletal Trafficking Brain Morphogenesis Dynein Complex Binding Retrograde Axonal Transport Vesicle Localization Protein Localization To Cilium Regulation Of Cytoskeleton Organization	Axon Dynein Complex Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Developmental Growth Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Differentiation Glutamatergic Synapse Ciliary Basal Body Nervous System Development Regulation Of Glycogen (starch) Synthase Activity Regulation Of Growth Tau Protein Binding Regulation Of Axonogenesis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Microtubule Spindle Pole Negative Regulation Of Catabolic Process Regulation Of Cell Differentiation Cell Projection Organization Cellular Response To Interleukin-3 Regulation Of Mitochondrial Membrane Permeability Regulation Of Type B Pancreatic Cell Development Centriolar Subdistal Appendage Regulation Of Neuron Projection Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Membrane Permeability Protein Kinase Binding Regulation Of Cell Adhesion Microtubule Anchoring At Centrosome Microtubule-based Process Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Axon Extension Beta-catenin Destruction Complex Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Protein Kinase A Catalytic Subunit Binding Establishment Of Organelle Localization Organelle Organization Camera-type Eye Photoreceptor Cell Differentiation Positive Regulation Of Nervous System Development Positive Regulation Of Catabolic Process Regulation Of Multicellular Organismal Development Establishment Of Vesicle Localization