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DCTN1 and DCTN3
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
DCTN1
DCTN3
Description
dynactin subunit 1
dynactin subunit 3
Image
No pdb structure
GO Annotations
Cellular Component
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Cytoskeleton
Microtubule
Microtubule Associated Complex
Cilium
Cell Cortex
Microtubule Cytoskeleton
Membrane
Dynein Complex
Axon
Retromer Complex
Cell Leading Edge
Protein-containing Complex
Microtubule Plus-end
Ciliary Basal Body
Neuron Projection
Neuronal Cell Body
Intercellular Bridge
Mitotic Spindle
Cell Cortex Region
Centriolar Subdistal Appendage
Chromosome, Centromeric Region
Kinetochore
Chromosome
Nucleolus
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Dynactin Complex
Microtubule Associated Complex
Midbody
Cleavage Furrow
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Tau Protein Binding
Structural Molecule Activity
Protein Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Migration
Nervous System Development
Neuromuscular Junction Development
Centriole-centriole Cohesion
Ventral Spinal Cord Development
Positive Regulation Of Microtubule Polymerization
Melanosome Transport
Microtubule Anchoring At Centrosome
Retrograde Transport, Endosome To Golgi
Neuromuscular Process
Nuclear Membrane Disassembly
Cell Division
Regulation Of Mitotic Spindle Organization
Motor Behavior
Neuron Cellular Homeostasis
Positive Regulation Of Microtubule Nucleation
Axonal Transport
Maintenance Of Synapse Structure
Positive Regulation Of Neuromuscular Junction Development
Non-motile Cilium Assembly
Neuron Projection Maintenance
Mitotic Cell Cycle
Microtubule-based Process
Cell Division
Cytoskeleton-dependent Cytokinesis
Pathways
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Signaling by ALK fusions and activated point mutants
MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2
Drugs
Diseases
Perry syndrome
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Distal hereditary motor neuropathies (dHMN)
GWAS
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Refractive error (
32231278
)
Appendicular lean mass (
33097823
)
Interacting Genes
52 interacting genes:
ACTR1A
ACTR1B
AKT1
APEX1
BBS1
BBS4
BICD1
BICD2
CASP2
CASP3
CASP7
CDC37
CLIP1
CTIF
DCTN3
DISC1
DST
DTNBP1
DYNC1I1
DYNC1I2
EEF1A1
ENO3
FBXL5
FXR1
GRB2
GSK3B
HAP1
HOXA1
HSPB2
KIAA0408
KIF11
LCOR
MAP2K3
MAP2K6
MAPRE1
MED14
MTERF1
NEK2
NOD2
PAFAH1B1
PFDN1
PGAM1
PPP1CA
RAB6A
RBL2
RPGR
SEC23A
SPTBN2
STAT1
TP53RK
VIM
ZNF512B
11 interacting genes:
ATXN1
DCTN1
GSK3B
KRT34
NUP54
PBX2
PITX1
TRIM55
TRIP13
USHBP1
VPS37C
Entrez ID
1639
11258
HPRD ID
07206
06303
Ensembl ID
ENSG00000204843
ENSG00000137100
Uniprot IDs
A0A7P0Z4C3
Q14203
O75935
X6RLR1
PDB IDs
1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
Enriched GO Terms of Interacting Partners
?
Cytosol
Centrosome
Microtubule-based Process
Transport Along Microtubule
Cytoskeleton
Cytoskeleton-dependent Intracellular Transport
Dynactin Binding
Microtubule-based Transport
Cytoplasm
Organelle Transport Along Microtubule
Microtubule-based Movement
Cytoskeleton Organization
Organelle Organization
Minus-end-directed Organelle Transport Along Microtubule
Protein Kinase Binding
Regulation Of Microtubule-based Process
Microtubule Cytoskeleton Organization
Establishment Of Organelle Localization
Microtubule Plus-end Binding
Microtubule Organizing Center
Execution Phase Of Apoptosis
Microtubule
Cell Cortex
Dynactin Complex
Organelle Assembly
Hippocampus Development
Positive Regulation Of Cilium Assembly
Axon
Ciliary Basal Body
Response To Light Stimulus
Microtubule Anchoring At Microtubule Organizing Center
Positive Regulation Of Cellular Component Organization
Response To Radiation
Pyroptotic Inflammatory Response
Perinuclear Region Of Cytoplasm
Vesicle Transport Along Microtubule
Regulation Of Microtubule Cytoskeleton Organization
Organelle Localization
Microtubule Cytoskeleton
Establishment Of Vesicle Localization
Non-motile Cilium Assembly
Protein Binding
Central Region Of Growth Cone
Vesicle Cytoskeletal Trafficking
Brain Morphogenesis
Dynein Complex Binding
Retrograde Axonal Transport
Vesicle Localization
Protein Localization To Cilium
Regulation Of Cytoskeleton Organization
Regulation Of Dendritic Cell Dendrite Assembly
CCR7 Chemokine Receptor Binding
Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Establishment Of T Cell Polarity
Negative Regulation Of Dendritic Cell Apoptotic Process
Chemokine Receptor Binding
Establishment Of Cell Polarity
Immunological Synapse Formation
Dendritic Cell Chemotaxis
Mononuclear Cell Migration
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Positive Regulation Of Glycoprotein Biosynthetic Process
Cellular Response To Prostaglandin E Stimulus
Eosinophil Chemotaxis
Positive Regulation Of Glycoprotein Metabolic Process
Eosinophil Migration
Myeloid Leukocyte Migration
Regulation Of Antigen Processing And Presentation
Dendritic Cell Migration
Positive Regulation Of Neutrophil Chemotaxis
Cellular Response To Prostaglandin Stimulus
Response To Prostaglandin E
Cell Maturation
Positive Regulation Of Granulocyte Chemotaxis
CCR Chemokine Receptor Binding
Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Neutrophil Migration
Regulation Of Neutrophil Chemotaxis
Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cellular Component Biogenesis
Neuron Projection Organization
Tau Protein Binding
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Developmental Maturation
Regulation Of Neutrophil Migration
T Cell Costimulation
Chemokine Activity
Leukocyte Migration
Regulation Of Cell Projection Assembly
Regulation Of Granulocyte Chemotaxis
Regulation Of Microtubule Anchoring At Centrosome
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Dendritic Cell Dendrite Assembly
Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Apoptotic Process
Release Of Sequestered Calcium Ion Into Cytosol
Cell-cell Recognition
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Tagcloud (Intersection)
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