DCTN1 and DCTN3

Number of citations of the paper that reports this interaction (PMID 9722614)
18

Data Source:
HPRD (in vitro)

		DCTN1	DCTN3
Gene Name		dynactin 1	dynactin 3 (p22)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge	Condensed Chromosome Kinetochore Centrosome Spindle Cytosol Dynactin Complex Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Motor Activity Protein Binding Dynein Binding	Structural Molecule Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Organelle Organization Microtubule-based Process Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B	4 interactors: ATXN1 DCTN1 GSK3B PBX2
Entrez ID		1639	11258
HPRD ID		07206	06303
Ensembl ID		ENSG00000204843	ENSG00000137100
Uniprot IDs		Q14203 Q6MZZ3	O75935
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process	ER-nucleus Signaling Pathway Positive Regulation Of Cellular Metabolic Process Nuclear Export Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport Cellular Response To Interleukin-3 Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Positive Regulation Of Gene Expression Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cellular Biosynthetic Process Protein Localization To Microtubule Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Phosphorylation ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Multicellular Organismal Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Developmental Process Regulation Of DNA Methylation Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization Regulation Of Gene Expression By Genetic Imprinting
Tagcloud ?		als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Difference) ?		als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Intersection) ?