DCTN1 and PPP1CA

Number of citations: 74 (PubMedID 22321011)
Data Source: BioGRID (two hybrid)

		DCTN1	PPP1CA
Name		dynactin subunit 1	protein phosphatase 1 catalytic subunit alpha
Structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cilium Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Cell Leading Edge Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Neuronal Cell Body Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Ribonucleoprotein Complex Binding Protein-containing Complex Binding Metal Ion Binding Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Melanosome Transport Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance	Telomere Maintenance RNA Polymerase II Promoter Clearance Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Response To Lead Ion Dephosphorylation Lung Development Circadian Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Telomere Maintenance In Response To DNA Damage Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Glycogen Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Protein Stabilization Cell Division Regulation Of Canonical Wnt Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining Cell-cell Adhesion Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants	Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		None	2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases		Perry syndrome Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)	None
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Refractive error ( 32231278 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Height ( 28552196 )
Interacting Genes		52 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 CTIF DCTN3 DISC1 DST DTNBP1 DYNC1I1 DYNC1I2 EEF1A1 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 LCOR MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B	173 interacting genes: AATK AHCTF1 AKAP1 AKAP11 AKAP9 AKT1 APAF1 ASPM AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDCA2 CDH1 CEP126 CEP170 CEP192 CKB CLCN2 CLOCK CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 ITGB8 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MECOM MIIP MKI67 MPHOSPH10 MST1R MYO16 NCAM1 NDP NEDD8 NEK2 NOC2L NOM1 NONO NOP53 PAK1 PBK PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHB2 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RORC RPRD2 RRP1B SAXO4 SEH1L SFI1 SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TRIM21 TSC2 TUSC3 UBC UBE2Z UBR5 ULK1 VDR WBP11 WDR82 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827
Entrez ID		1639	5499
HPRD ID		07206	15942
Ensembl ID		ENSG00000204843	ENSG00000172531
Uniprot IDs		A0A7P0Z4C3 Q14203	A0A140VJS9 P62136
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7	3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ 6ZK6 7QFB 7QM2 7T0Y 7TVF 7TXH 7UPI 8DWK 8DWL 8SW5 8SW6 8U5G
GO Terms Enriched among Interactors		Cytosol Centrosome Microtubule-based Process Transport Along Microtubule Cytoskeleton Cytoskeleton-dependent Intracellular Transport Dynactin Binding Microtubule-based Transport Cytoplasm Organelle Transport Along Microtubule Microtubule-based Movement Cytoskeleton Organization Organelle Organization Minus-end-directed Organelle Transport Along Microtubule Protein Kinase Binding Regulation Of Microtubule-based Process Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Microtubule Plus-end Binding Microtubule Organizing Center Execution Phase Of Apoptosis Microtubule Cell Cortex Dynactin Complex Organelle Assembly Hippocampus Development Positive Regulation Of Cilium Assembly Axon Ciliary Basal Body Response To Light Stimulus Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Cellular Component Organization Response To Radiation Pyroptotic Inflammatory Response Perinuclear Region Of Cytoplasm Vesicle Transport Along Microtubule Regulation Of Microtubule Cytoskeleton Organization Organelle Localization Microtubule Cytoskeleton Establishment Of Vesicle Localization Non-motile Cilium Assembly Protein Binding Central Region Of Growth Cone Vesicle Cytoskeletal Trafficking Brain Morphogenesis Dynein Complex Binding Retrograde Axonal Transport Vesicle Localization Protein Localization To Cilium Regulation Of Cytoskeleton Organization	Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Intracellular Signal Transduction Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Cycle Enzyme Binding Regulation Of Intracellular Signal Transduction Nucleoplasm Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Nucleus Glycogen Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Glycogen Binding Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cytoplasm Positive Regulation Of Metabolic Process Polysaccharide Metabolic Process Energy Reserve Metabolic Process Cell Population Proliferation Release Of Cytochrome C From Mitochondria Chromosome Response To Radiation Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Programmed Cell Death Response To Starvation Regulation Of Glycogen Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Oxygen-containing Compound Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex