FANCC and HSPA1A

Number of citations of the paper that reports this interaction (PMID 11500375)
25

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo)

		FANCC	HSPA1A
Gene Name		Fanconi anemia, complementation group C	heat shock 70kDa protein 1A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding
	Biological Process	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Protein Complex Assembly Germ Cell Development Removal Of Superoxide Radicals	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Fanconi Anemia pathway	Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATP6 AZIN1 CAPN10 CDK1 DNAJB1 FANCA FANCD2 FANCE FANCF FANCG GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRT1 POR RPL18 RPS3A SPTA1 SPTAN1 STAT1 TCERG1 USP14 ZBTB32	79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		2176	3303
HPRD ID		01967	00774
Ensembl ID		ENSG00000158169	ENSG00000204389
Uniprot IDs		B4E3W2 Q00597	A8K5I0 B3KTT5 P08107
PDB IDs			1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F
Enriched GO Terms of Interacting Partners?		Protein Refolding Response To Unfolded Protein Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Stress Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA Repair Response To Stimulus Protein Import Into Mitochondrial Outer Membrane Response To Heat Protein Folding Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Membrane Organization Cellular Metabolic Process Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Inclusion Body Assembly Response To Temperature Stimulus Axon Guidance Response To Oxidative Stress Response To External Stimulus Chaperone-mediated Protein Complex Assembly DNA Metabolic Process Establishment Of Protein Localization To Membrane Nucleobase-containing Compound Metabolic Process Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Apoptotic Process Cellular Response To Organonitrogen Compound Regulation Of Inclusion Body Assembly Regulation Of Cell Death Protein Localization To Organelle Female Gonad Development Axonogenesis Development Of Primary Female Sexual Characteristics Cellular Macromolecule Catabolic Process Viral Process Cellular Response To Peptide Hormone Stimulus Axon Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Peptide Nitric Oxide Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Metabolic Process	Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process
Tagcloud ?		1beta autoinhibitory bm characterizes creating cytokines fanca fanconi hypersensitive inactivated leukemic loop mapkapk mononuclear multipotent overproduced overproduction p38 phagocytes posttranscriptionally potently progenitor progenitors progressive reasoning tlr toll transcriptionally	chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		1beta autoinhibitory bm characterizes creating cytokines fanca fanconi hypersensitive inactivated leukemic loop mapkapk mononuclear multipotent overproduced overproduction p38 phagocytes posttranscriptionally potently progenitor progenitors progressive reasoning tlr toll transcriptionally	chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?