FANCC and STMN2

Number of citations: 60 (PubMedID 26466335)
Data Source: BioGRID (two hybrid, two hybrid)

		FANCC	STMN2
Name		FA complementation group C	stathmin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Cytoplasm Endosome Golgi Apparatus Cytosol Membrane Lamellipodium Axon Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Tubulin Binding Calcium-dependent Protein Binding
	Biological Process	DNA Repair Nucleotide-excision Repair DNA Damage Response Cellular Response To Oxidative Stress Interstrand Cross-link Repair Protein-containing Complex Assembly	Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Depolymerization Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes PKR-mediated signaling	RND1 GTPase cycle
Diseases		Fanconi anemia	None
GWAS		Birth weight ( 31043758 ) Hematocrit ( 32888494 ) Offspring birth weight ( 31043758 ) Polycystic ovary syndrome ( 26284813 )	Creutzfeldt-Jakob disease ( 19081515 ) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592 ) Metabolite levels ( 23823483 ) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 )
Interacting Genes		54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32	28 interacting genes: CCDC85A CCHCR1 CDC42 CDK1 CEP70 CTNNA3 EEF1A1 ERBB2 FAM90A1 FANCC GPRASP1 GPRASP2 MAPK10 MAPK3 MBD3 NGFR NTAQ1 PRKACA PSMB1 PSMC1 RGS20 RGS6 SESTD1 TEX11 TFCP2 TRPC5 TXLNA UBE2I
Entrez ID		2176	11075
HPRD ID		01967	09003
Ensembl ID		ENSG00000158169	ENSG00000104435
Uniprot IDs		A0A024R9N2 A0A087WW44 B4E3W2 Q00597	Q93045
PDB IDs		7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	Not available
GO Terms Enriched among Interactors		Cytosol Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Supramolecular Fiber Organization Cellular Response To Stress Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Component Organization Negative Regulation Of Cytoskeleton Organization Response To Hormone Response To Growth Factor Fanconi Anaemia Nuclear Complex Cellular Response To Peptide Hormone Stimulus ATP-dependent Protein Folding Chaperone Cellular Response To Hormone Stimulus Interstrand Cross-link Repair Nucleoplasm Regulation Of Supramolecular Fiber Organization Response To Steroid Hormone Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Cadherin Binding Positive Regulation Of Cell Population Proliferation Nucleus Focal Adhesion Protein Folding Chaperone Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Multicellular Organismal Process DNA Repair Regulation Of Immune System Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein-containing Complex Disassembly DNA Damage Response Intracellular Signal Transduction Response To Peptide Hormone Regulation Of Cytoskeleton Organization Response To Lipid G1/S Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Macromolecule Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition Response To Unfolded Protein Regulation Of Cellular Component Organization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Depolymerization	Cytosol Calcium Channel Complex Cytoplasm Response To Epidermal Growth Factor ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Phosphorylation Intracellular Signaling Cassette Phosphorylation Neuromuscular Junction MAP Kinase Activity