FANCC and PTPRJ

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		FANCC	PTPRJ
Description		FA complementation group C	protein tyrosine phosphatase receptor type J
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Immunological Synapse Extracellular Region Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Cell Surface Membrane Nuclear Body Cell Junction Ruffle Membrane Specific Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	DNA Repair Nucleotide-excision Repair DNA Damage Response Cellular Response To Oxidative Stress Interstrand Cross-link Repair Protein-containing Complex Assembly	Angiogenesis Vasculogenesis Positive Regulation Of Cell-matrix Adhesion Immune System Process Signal Transduction Axon Guidance Heart Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Hemopoiesis Regulation Of Cell Adhesion B Cell Differentiation Platelet Formation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of Insulin Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Contact Inhibition Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes PKR-mediated signaling	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
Drugs
Diseases		Fanconi anemia
GWAS		Birth weight ( 31043758) Hematocrit ( 32888494) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)	Acute lymphoblastic leukemia (childhood) ( 22076464) Alanine aminotransferase levels ( 33547301) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Caffeine consumption from coffee or tea ( 33287642) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 31798171 31959993 30054594 29785010 29617998 29235454 25173106) Kawasaki disease ( 33692975) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163) Sleep duration (short sleep) ( 30846698)
Interacting Genes		54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32	37 interacting genes: ANP32B BAAT BAP1 CASC3 CNKSR1 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510
Entrez ID		2176	5795
HPRD ID		01967	02955
Ensembl ID		ENSG00000158169	ENSG00000149177
Uniprot IDs		A0A024R9N2 A0A087WW44 B4E3W2 Q00597	Q12913 Q9NPR5
PDB IDs		7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	2CFV 2DLE 2NZ6 7U01 7U08
Enriched GO Terms of Interacting Partners?		Cytosol Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Supramolecular Fiber Organization Cellular Response To Stress Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Component Organization Negative Regulation Of Cytoskeleton Organization Response To Hormone Response To Growth Factor Fanconi Anaemia Nuclear Complex Cellular Response To Peptide Hormone Stimulus ATP-dependent Protein Folding Chaperone Cellular Response To Hormone Stimulus Interstrand Cross-link Repair Nucleoplasm Regulation Of Supramolecular Fiber Organization Response To Steroid Hormone Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Cadherin Binding Positive Regulation Of Cell Population Proliferation Nucleus Focal Adhesion Protein Folding Chaperone Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Multicellular Organismal Process DNA Repair Regulation Of Immune System Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein-containing Complex Disassembly DNA Damage Response Intracellular Signal Transduction Response To Peptide Hormone Regulation Of Cytoskeleton Organization Response To Lipid G1/S Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Macromolecule Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition Response To Unfolded Protein Regulation Of Cellular Component Organization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Depolymerization	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Catenin-TCF7L2 Complex Phospholipase C Activator Activity ERBB Signaling Pathway Cellular Response To Indole-3-methanol Positive Regulation Of MAPK Cascade Catenin Complex Cell Morphogenesis Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Signal Transduction Response To Indole-3-methanol Cell-cell Junction Trachea Formation Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activity Alpha-catenin Binding Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Vasculature Development Regulation Of Cell Motility Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Transport Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Transport Intracellular Signaling Cassette Tube Morphogenesis Regulation Of MAPK Cascade Histone Methyltransferase Binding Regulation Of Cell Population Proliferation Ciliary Basal Body Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Adherens Junction
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