SPRR2A and CTTN

Number of citations of the paper that reports this interaction (PMID 18155796)
10

Data Source:
BioGRID (pull down)

		SPRR2A	CTTN
Gene Name		small proline-rich protein 2A	cortactin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cornified Envelope Cytoplasm	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Epidermis Development Keratinocyte Differentiation Keratinization	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1	36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1
Entrez ID		6700	2017
HPRD ID		01649	01268
Ensembl ID		ENSG00000241794	ENSG00000085733
Uniprot IDs		P35326	Q14247 Q53HG7
PDB IDs			1X69 2D1X
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Protein Autophosphorylation Phagocytosis Positive Regulation Of Immune Response Locomotion Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Anatomical Structure Development Cellular Response To Peptide Vesicle-mediated Transport Innate Immune Response Movement Of Cell Or Subcellular Component Regulation Of Actin Cytoskeleton Organization Response To Organonitrogen Compound Regulation Of Vesicle-mediated Transport Cell Migration Regulation Of Immune Response Developmental Process Regulation Of Actin Filament-based Process Positive Regulation Of Immune System Process Cell Motility Regulation Of Organelle Organization Neurogenesis Response To Peptide Hormone Dendritic Spine Organization System Development Response To Peptide Phosphorylation Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Endocytosis Cellular Response To Hormone Stimulus Multicellular Organismal Development Immune Response Neuron Projection Morphogenesis Regulation Of Immune System Process Protein Phosphorylation Transport	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization
Tagcloud ?		200c bec biliary cc cholangiocarcinogenesis cholangiocarcinomas ck19 ctbp dephosphorylation emt healing intrahepatic invasiveness labeling microrna modulates morphometric multiplex nonneoplastic proline protects proteomic quenches radicals sh3 synergic wound zeb zeb1	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Difference) ?		200c bec biliary cc cholangiocarcinogenesis cholangiocarcinomas ck19 ctbp dephosphorylation emt healing intrahepatic invasiveness labeling microrna modulates morphometric nonneoplastic proline protects proteomic quenches radicals sh3 synergic wound zeb zeb1	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Intersection) ?		multiplex