SPRR2A and ITK

Number of citations: 59 (PubMedID 18155796)
Data Source: BioGRID (pull down)

		SPRR2A	ITK
Name		small proline rich protein 2A	IL2 inducible T cell kinase
Structure		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Cytosol Transport Vesicle Secretory Granule Cytoplasmic Vesicle	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Binding Lipid Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Antibacterial Humoral Response Defense Response To Bacterium Host-mediated Modulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium	Positive Regulation Of Cytokine Production NK T Cell Differentiation Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Intracellular Signal Transduction T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		None	Staurosporine Pazopanib Fostamatinib Zanubrutinib
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 )	Asthma ( 31959851 34103634 ) Daytime sleep phenotypes ( 27126917 ) Eosinophil count ( 32888494 ) Heel bone mineral density ( 30598549 ) Personality traits in bipolar disorder ( 21368711 ) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577 )
Novel Interactors		1 novel interactors: PSMG1	1 novel interactors: PDGFRB
Interacting Genes		10 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1	34 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS
Entrez ID		6700	3702
HPRD ID		01649	01746
Ensembl ID		ENSG00000241794	ENSG00000113263
Uniprot IDs		P35326	Q08881
PDB IDs		Not available	1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM
GO Terms Enriched among Interactors		Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Cytosol Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Kinase Activity Regulation Of Immune Response Response To Transforming Growth Factor Beta Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Motility Actin Filament Immune Response-regulating Cell Surface Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-activating Signaling Pathway Proline-rich Region Binding Regulation Of Actin Filament-based Process Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Cellular Response To Oxygen-containing Compound Response To Reactive Oxygen Species Ephrin Receptor Binding Cell Migration Cortical Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Dendritic Spine Organization Positive Regulation Of Cytoskeleton Organization Protein Modification Process Regulation Of Cytoskeleton Organization Negative Regulation Of Immune Response Regulation Of Biological Quality Intracellular Protein Localization SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Postsynapse Organization Postsynapse Leukocyte Migration Positive Regulation Of Locomotion	Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Activation Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Phospholipase Binding ERBB Signaling Pathway Regulation Of Apoptotic Process Immune System Process Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Intracellular Signaling Cassette Leukocyte Activation Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Kinase Activity Regulation Of Immune Response Regulation Of MAPK Cascade Membrane Raft Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Binding